Fig. 1

CSF analyte levels (Z scores) for the combined cohort of normal cognition without CSF biomarkers consistent with Alzheimer’s disease (NC^–) and Alzheimer’s disease (AD) dementia subjects. To account for inter-center variability, a center-specific Z score was calculated for each analyte by grouping NC^– and AD dementia subjects together to calculate the group mean and standard deviation. Student’s t tests were then used to compare the Z scores of NC^– and AD dementia subjects across the three centers, with FDR < 5%. Bars represent median and interquartile ranges, and the unadjusted p values are shown. Fabp3 fatty acid binding protein 3, IL interleukin, MCP-1 monocyte chemotactic protein 1, NfL neurofilament light chain, TNF tumor necrosis factor, YKL40 chitinase-3-like protein 1