Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study

Table 4 Curvilinear associations between functional inter-network connectivity, amyloid-beta burden, and memory decline

Fitted model	Est.	SE	95% CI	DF	T value	p value	p value (FDR)
Whole sample, excluding AD group (n = 91, number of observations = 364)
DMN-DAN (n = 91, number of observations = 364)
DMN-DAN × Aβ × (Time²)	0.42	0.16	0.10 to 0.74	266	2.60	0.01	0.02
DMN-SN (n = 91, number of observations = 364)
DMN-SN × Aβ × (Time²)	0.25	0.14	−0.02 to 0.52	266	1.84	0.07	0.07
Subset of participants with positive correlation between DMN and DAN^b
Whole sample, excluding AD group (n = 39, number of observations = 157)
Aβ × Time	−0.43	0.15	−0.73 to −0.13	116	−2.83	0.01	0.01
CN (n = 10, number of observations = 43)
Aβ × Time	0.22	0.20	−0.19 to 0.63	31	1.08	0.29	0.29
MCI (n = 29, number of observations = 114)
Aβ × Time	−0.44	0.13	−0.69 to −0.18	83	−3.43	0.001	0.001
Subset of participants with negative correlation between DMN and DAN^a
Whole sample. Excluding AD group (n = 52, number of observations = 207)
Aβ × (Time²)	−0.05	0.01	−0.07 to − 0.03	152	−4.23	< 0.001	< 0.001
CN (n = 18, number of observations = 75)
Aβ × (Time²)	−0.25	0.08	−0.41 to − 0.10	53	−3.33	0.001	0.001
MCI (n = 34, number of observations = 132)
Aβ × Time	− 0.26	0.15	− 0.56 to 0.04	96	−1.73	0.09	0.09

Regression models are adjusted for age, intracranial volume, sex and education
Beta coefficients are unstandardized
Aβ amyloid-beta, AD Alzheimer’s disease, CI confidence interval, CN cognitively normal, DAN dorsal attention network, DF degrees of freedom, DMN default mode network, FDR false discovery rate, MCI mild cognitive impairment, SE standard error, SN salience network
^a Models include a quadratic term only if it explained more variance than the linear model without quadratic term

ISSN: 1758-9193