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Table 4 Curvilinear associations between functional inter-network connectivity, amyloid-beta burden, and memory decline

From: Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study

Fitted model Est. SE 95% CI DF T value p value p value (FDR)
Whole sample, excluding AD group (n = 91, number of observations = 364)
DMN-DAN (n = 91, number of observations = 364)
 DMN-DAN × Aβ × (Time2) 0.42 0.16 0.10 to 0.74 266 2.60 0.01 0.02
DMN-SN (n = 91, number of observations = 364)
 DMN-SN × Aβ × (Time2) 0.25 0.14 −0.02 to 0.52 266 1.84 0.07 0.07
Subset of participants with positive correlation between DMN and DANb
Whole sample, excluding AD group (n = 39, number of observations = 157)
 Aβ × Time −0.43 0.15 −0.73 to −0.13 116 −2.83 0.01 0.01
CN (n = 10, number of observations = 43)
 Aβ × Time 0.22 0.20 −0.19 to 0.63 31 1.08 0.29 0.29
MCI (n = 29, number of observations = 114)
 Aβ × Time −0.44 0.13 −0.69 to −0.18 83 −3.43 0.001 0.001
Subset of participants with negative correlation between DMN and DANa
Whole sample. Excluding AD group (n = 52, number of observations = 207)
 Aβ × (Time2) −0.05 0.01 −0.07 to − 0.03 152 −4.23 < 0.001 < 0.001
CN (n = 18, number of observations = 75)
 Aβ × (Time2) −0.25 0.08 −0.41 to − 0.10 53 −3.33 0.001 0.001
MCI (n = 34, number of observations = 132)
 Aβ × Time − 0.26 0.15 − 0.56 to 0.04 96 −1.73 0.09 0.09
  1. Regression models are adjusted for age, intracranial volume, sex and education
  2. Beta coefficients are unstandardized
  3. amyloid-beta, AD Alzheimer’s disease, CI confidence interval, CN cognitively normal, DAN dorsal attention network, DF degrees of freedom, DMN default mode network, FDR false discovery rate, MCI mild cognitive impairment, SE standard error, SN salience network
  4. a Models include a quadratic term only if it explained more variance than the linear model without quadratic term