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Table 3 Three-way interaction of functional connectivity, amyloid-beta, and time in the cognitively normal group

From: Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study

Fitted model Est. SE 95% CI DF T value p value p value (FDR)
DMN-DAN (n = 28, number of observations = 118)
 DMN-DAN × Aβ × Time 1.97 0.48 1.03 to 2.92 86 4.14 < 0.001 < 0.001
DMN-SN (n = 28, number of observations = 118)
 DMN-SN × Aβ × Time 1.86 0.56 0.74 to 2.97 86 3.31 0.001 0.001
DMN-FPN (n = 28, number of observations = 118)
 DMN-FPN × Aβ × Time −0.62 0.97 −2.55 to 1.30 86 −0.64 0.52 0.52
  1. Regression models are adjusted for age, intracranial volume, sex and education
  2. Beta coefficients are unstandardized
  3. amyloid-beta, CI confidence interval, DAN dorsal attention network, DF degrees of freedom, DMN default mode network, FPN frontoparietal network, SE standard error, SN salience network