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Table 3 Three-way interaction of functional connectivity, amyloid-beta, and time in the cognitively normal group

From: Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study

Fitted model

Est.

SE

95% CI

DF

T value

p value

p value (FDR)

DMN-DAN (n = 28, number of observations = 118)

 DMN-DAN × Aβ × Time

1.97

0.48

1.03 to 2.92

86

4.14

< 0.001

< 0.001

DMN-SN (n = 28, number of observations = 118)

 DMN-SN × Aβ × Time

1.86

0.56

0.74 to 2.97

86

3.31

0.001

0.001

DMN-FPN (n = 28, number of observations = 118)

 DMN-FPN × Aβ × Time

−0.62

0.97

−2.55 to 1.30

86

−0.64

0.52

0.52

  1. Regression models are adjusted for age, intracranial volume, sex and education
  2. Beta coefficients are unstandardized
  3. Aβ amyloid-beta, CI confidence interval, DAN dorsal attention network, DF degrees of freedom, DMN default mode network, FPN frontoparietal network, SE standard error, SN salience network
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Alzheimer's Research & Therapy

ISSN: 1758-9193