Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study

Table 2 Associations between group, inter-network functional connectivity, and memory decline

Fitted model	Est.	SE	95% CI	DF	T value	p value	p value (FDR)
DMN-DAN (n = 115, number of observations = 433)
Time × MCI^– × DMN-DAN	−0.43	0.22	−0.68 to −0.01	310	−2.00	0.047	0.14
Time × MCI⁺ × DMN-DAN	−0.79	0.23	−1.25 to −0.34	310	−3.43	0.001	0.001
Time × AD × DMN-DAN	−0.24	0.30	−0.84 to 0.36	310	−0.79	0.43	0.43
DMN-SN (n = 115, number of observations = 433)
Time × MCI^– × DMN-SN	−0.26	0.23	−0.71 to 0.19	310	−1.13	0.26	0.32
Time × MCI⁺ × DMN-SN	−0.55	0.20	−0.93 to −0.16	310	−2.81	0.01	0.01
Time × AD × DMN-SN	−0.36	0.31	−0.98 to 0.25	310	−1.17	0.25	0.37
DMN-FPN (n = 115, number of observations = 433)
Time × MCI^– × DMN-FPN	−0.27	0.27	−0.81 to 0.26	310	−1.00	0.32	0.32
Time × MCI⁺ × DMN-FPN	−0.21	0.26	−0.72 to 0.30	310	−0.81	0.42	0.42
Time × AD × DMN-FPN	−0.45	0.33	−1.09 to 0.19	310	−1.38	0.17	0.37

Results are acquired using the cognitively normal group as a reference group
Regression models are adjusted for age, intracranial volume, sex, and education
Beta coefficients are unstandardized
AD Alzheimer’s disease, CI confidence interval, DAN dorsal attention network, DF degrees of freedom, DMN default mode network, FDR false discovery rate, FPN frontoparietal network, MCI mild cognitive impairment, SE standard error, SN salience network

ISSN: 1758-9193