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Table 2 Associations between group, inter-network functional connectivity, and memory decline

From: Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study

Fitted model Est. SE 95% CI DF T value p value p value (FDR)
DMN-DAN (n = 115, number of observations = 433)
 Time × MCI × DMN-DAN −0.43 0.22 −0.68 to −0.01 310 −2.00 0.047 0.14
 Time × MCI+ × DMN-DAN −0.79 0.23 −1.25 to −0.34 310 −3.43 0.001 0.001
 Time × AD × DMN-DAN −0.24 0.30 −0.84 to 0.36 310 −0.79 0.43 0.43
DMN-SN (n = 115, number of observations = 433)
 Time × MCI × DMN-SN −0.26 0.23 −0.71 to 0.19 310 −1.13 0.26 0.32
 Time × MCI+ × DMN-SN −0.55 0.20 −0.93 to −0.16 310 −2.81 0.01 0.01
 Time × AD × DMN-SN −0.36 0.31 −0.98 to 0.25 310 −1.17 0.25 0.37
DMN-FPN (n = 115, number of observations = 433)
 Time × MCI × DMN-FPN −0.27 0.27 −0.81 to 0.26 310 −1.00 0.32 0.32
 Time × MCI+ × DMN-FPN −0.21 0.26 −0.72 to 0.30 310 −0.81 0.42 0.42
 Time × AD × DMN-FPN −0.45 0.33 −1.09 to 0.19 310 −1.38 0.17 0.37
  1. Results are acquired using the cognitively normal group as a reference group
  2. Regression models are adjusted for age, intracranial volume, sex, and education
  3. Beta coefficients are unstandardized
  4. AD Alzheimer’s disease, CI confidence interval, DAN dorsal attention network, DF degrees of freedom, DMN default mode network, FDR false discovery rate, FPN frontoparietal network, MCI mild cognitive impairment, SE standard error, SN salience network