Table 1 Descriptive characteristics of the four groups and comparisons (multinomial logistic regression)
Univariate analysis | Multivariate analysis | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AD (n = 135,664) | DLB (n = 10,309) | PDD (n = 3198) | PD (n = 8744) | AD | DLB | PDD | PD | ||||||||
Mean | [SD] | Mean | [SD] | Mean | [SD] | Mean | [SD] | Adjusted OR | [95% CI] | Adjusted OR | Adjusted OR | [95% CI] | Adjusted OR | [95% CI] | |
Age at first consultation with the diagnosis, years | 81.42 | [7.98] | 80.11 | [7.84] | 79.45 | [8.09] | 73.86 | [10.79] | 1.01** | [1.01; 1.01] | 1 | 0.99** | [0.99; 0.99] | 0.97** | [0.96; 0.97] |
MMSE at ± 1 year after diagnosis | 17.71 | [5.93] | 18.48 | [6.24] | 19.18 | [5.96] | 24.26 | [5.22] | 0.98** | [0.98; 0.99] | 1 | 1.03** | [1.02; 1.04] | 1.26** | [1.25; 1.27] |
No. | (%) | No. | (%) | No. | (%) | No. | (%) | Adjusted OR | [95% CI] | Adjusted OR | Adjusted OR | [95% CI] | Adjusted OR | [95% CI] | |
Sex | |||||||||||||||
Female | 95,098 | (70.1) | 5635 | (54.7) | 1452 | (45.4) | 3765 | (43.1) | 1.83** | [1.75; 1.92] | 1 | 0.70** | [0.64; 0.76] | 0.86** | [0.81; 0.93] |
Male | 40,566 | (29.9) | 4674 | (45.3) | 1746 | (54.6) | 4979 | (56.9) | 1 | 1 | 1 | 1 | |||
Type of center | |||||||||||||||
Memory clinic | 101,012 | (74.5) | 6712 | (65.1) | 2385 | (74.6) | 4798 | (54.9) | 1 | 1 | 1 | 1 | |||
Regional specialized memory clinic | 31,320 | (23.1) | 3226 | (31.3) | 695 | (21.7) | 3508 | (40.1) | 0.76** | [0.73; 0.80] | 1 | 0.54** | [0.48; 0.60] | 0.87** | [0.80; 0.94] |
Private practice neurologist | 3332 | (2.5) | 368 | (3.6) | 118 | (3.7) | 438 | (5.0) | 0.66** | [0.59; 0.75] | 1 | 0.95 | [0.75; 1.20] | 1.18* | [1.00; 1.40] |
Education | |||||||||||||||
No education | 11,075 | (8.2) | 663 | (6.4) | 194 | (6.1) | 334 | (3.8) | 1.22** | [1.09; 1.36] | 1 | 1.20 | [0.95; 1.52] | 1.88** | [1.57; 2.26] |
Primary | 64,430 | (47.5) | 4484 | (43.5) | 1327 | (41.5) | 2471 | (28.3) | 1.06 | [0.98; 1.14] | 1 | 1.16 | [0.99; 1.35] | 1.25** | [1.11; 1.39] |
Secondary first cycle | 21,516 | (15.9) | 1759 | (17.1) | 517 | (16.2) | 1595 | (18.3) | 1.04 | [0.96; 1.14] | 1 | 1.07 | [0.90; 1.28] | 1.19** | [1.05; 1.34] |
Secondary second cycle | 11,971 | (8.8) | 945 | (9.2) | 241 | (7.5) | 1027 | (11.8) | 1.11* | [1.01; 1.23] | 1 | 1.00 | [0.82; 1.23] | 1.28** | [1.11; 1.47] |
Superior | 10,510 | (7.8) | 1110 | (10.8) | 317 | (9.9) | 1308 | (15.0) | 1 | 1 | 1 | 1 | |||
Unknown | 16,162 | (11.9) | 1348 | (13.1) | 602 | (18.8) | 2009 | (23.0) | 1.00 | [0.91; 1.11] | 1 | 1.92** | [1.59; 2.30] | 2.78** | [2.44; 3.18] |
Initially referred by | |||||||||||||||
General practitioner | 90,354 | (66.6) | 5740 | (55.7) | 1562 | (48.8) | 3917 | (44.8) | 1 | 1 | 1 | 1 | |||
Neurologist | 7876 | (5.8) | 1118 | (10.8) | 526 | (16.5) | 2319 | (26.5) | 0.56** | [0.52; 0.61] | 1 | 1.72** | [1.49; 1.99] | 1.98** | [1.79; 2.19] |
Other specialists | 14,136 | (10.4) | 1406 | (13.6) | 392 | (12.3) | 679 | (7.8) | 0.67** | [0.63; 0.72] | 1 | 1.05 | [0.91; 1.21] | 0.75** | [0.66; 0.84] |
Direct | 5807 | (4.3) | 389 | (3.8) | 105 | (3.3) | 343 | (3.9) | 0.96 | [0.85; 1.08] | 1 | 1.11 | [0.87; 1.42] | 1.02 | [1.85; 1.23] |
Others | 17,488 | (12.9) | 1656 | (16.1) | 613 | (19.2) | 1486 | (17.0) | 0.65** | [0.61; 0.70] | 1 | 1.32** | [1.16; 1.49] | 1.82** | [1.65; 2.01] |
Community-dwelling | |||||||||||||||
No | 22,756 | (16.8) | 2045 | (19.8) | 778 | (24.3) | 1239 | (14.2) | 1 | 1 | 1 | 1 | |||
Yes | 112,908 | (83.2) | 8267 | (80.2) | 2420 | (75.7) | 7505 | (85.8) | 1.37** | [1.29; 1.45] | 1 | 0.71** | [0.63; 0.79] | 0.79** | [0.71; 0.87] |
Location of the patient | |||||||||||||||
Within 50 km from the memory clinic | 124,519 | (91.8) | 9220 | (89.4) | 2899 | (90.7) | 6816 | (78.0) | 1.08* | [1.00; 1.16] | 1 | 0.97 | [0.84; 1.13] | 0.61** | [0.55; 0.67] |
> 50 km from the memory clinic | 11,145 | (8.2) | 1089 | (10.6) | 299 | (9.4) | 1928 | (22.0) | 1 | 1 | 1 | 1 | |||