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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study

Fig. 1

Individual atabecestat (JNJ-54861911) pharmacokinetic (PK) parameters at steady state for AUC0–24 h (a) and maximum plasma concentration (Cmax) (b) vs. dose groups based on population PK model in Caucasian patients with early Alzheimer’s disease (ALZ1005) and in healthy elderly in the multiple ascending dose study (ALZ1002). Pharmacokinetic parameters were dose-normalized to 5 mg for all treatment and participant groups

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