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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer’s disease

Fig. 4

Intra-DMN functional connectivity relates to memory and executive/attention function in subjects without cerebrovascular disease and memory in subjects with cerebrovascular disease. Representative regions showing associations between intra-DMN functional connectivity and cognition. In aMCI and AD subjects without CeVD, a FC between mPFC and left superior mid frontal gyrus was negatively associated attention function while b higher parietal FC between PCC and right angular gyrus was associated with higher verbal memory and c higher temporoparietal FC between lParaHC and bilateral PCUN was associated with better visual memory. In AD and aMCI subjects with CeVD, d higher temporoparietal FC between the lParaHC and bilateral middle cingulate gyrus was positively associated with visual memory. All FC cognitions shown pass the multiple comparisons correction for number of cognitive domains at p < 0.0125. AD Alzheimer’s disease, aMCI amnestic mild cognitive impairment, ANG right angular gyrus, bil bilateral, CeVD cerebrovascular disease, DLFPC dorsolateral prefrontal cortex, DMN default mode network, FC functional connectivity, l left, MCG middle cingulate gyrus, mPFC medial prefrontal cortex, ParaHC parahippocampal cortex, PCC posterior cingulate cortex, PCUN precuneus, r right, SC structural connectivity

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