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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: IgM response against amyloid-beta in aging: a potential peripheral protective mechanism

Fig. 5

Amyloid-beta (Aβ)42 peptide-specific antibodies of IgM isotype are decreased in Alzheimer’s disease (AD) patients compared with healthy controls (HC). The levels of Aβ42-specific antibodies as well as Aβ scrambled peptide were measured from the plasma samples of AD patients, those with mild cognitive impairment (MCI), and age-matched healthy controls. a Dot plots depict the ratio of Aβ42-specific IgG and IgM antibodies to scrambled peptide antibodies. b Dot plot depicts the levels of IL-21 in the same samples. Results are shown as mean ± SD of 26 AD patients, 26 MCI patients, and 26 healthy controls. p values are based on one0way ANOVA followed by Tukey’s test with two tails and 95% confidence interval

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