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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: IgM response against amyloid-beta in aging: a potential peripheral protective mechanism

Fig. 1

Dendritic cells (DCs) from aged subjects display increased secretion of inflammatory chemokines and cytokines in response to amyloid-beta (Aβ) peptide. DCs from healthy aged and young subjects were cultured overnight with Aβ42 peptide (pep), Aβ fibril (fib), and tau protein at 10 μg/ml. Cytokine secretion in the supernatants was quantified by ELISA. Bar graphs depict the levels of a chemokines (C-X-C motif chemokine 10 (CXCL-10), C-C motif chemokine ligand (CCL)-4, and CCL-2) and b cytokines (interleukin (IL)-6 and IL-1β). Results are shown as mean ± SEM of 18 different aged and 18 different young subjects. p values are based on two-tailed, parametric paired t tests with 95% confidence interval. Comparison of stimulated DCs in each group was performed against the control of the same age group

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