Fig. 3

Regions showing significant difference in cerebral glucose metabolism from voxel-wise analyses. a FH⁺APOE4⁺ compared with FH⁺APOE4^–. b FH⁺APOE4⁺ compared with FH^–APOE4⁺. c FH⁺APOE4⁺ compared with FH^–APOE4^–. APOE4 apolipoprotein ε4 allele, APOE4⁺ APOE4 carriers, APOE4^– APOE4 noncarriers, FH family history of Alzheimer’s disease, FH⁺ individuals with FH, FH^– individuals without FH, L left hemisphere, R right hemisphere