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Table 2 Table of genome-wide significant rQTL p values based on 200 million parametric bootstraps

From: Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels

Trait pair SNP Chrom Location Maj/Min (MAF) p value Gene Left gene Right gene
tau/Aβ42 rs74131475 1 194252450 C/T (0.089) 3.33 × 10–8 LOC107985242 EEF1A1P14 RNU6-983P
tau/Aβ42 rs1936361 10 102370841 C/T (0.444) 5.00 × 10–9   HIF1AN PAX2
tau/Aβ42 rs118023102 16 75983693 G/A (0.027) 3.33 × 10–8   LOC105371348 LOC105371349
tau/Aβ42 rs74025622a 16 75999881 A/G (0.028) < 5 × 10–9   LOC105371348 LOC105371349
p-tau/Aβ42 rs15205b,c 3 44966906 A/T (0.028) < 5 × 10–9 ZDHHC3 TGM4 EXOSC7
p-tau/Aβ42 rs79099429b,c 3 44993764 T/C (0.029) < 5 × 10–9 ZDHHC3 TGM4 EXOSC7
p-tau/Aβ42 rs689167 6 52785560 G/A (0.362) < 5 × 10–9   GSTA3 GSTA9P
p-tau/Aβ42 rs1036819a 8 135611945 A/C (0.261) < 5 × 10–9 ZFAT LOC100129104 LOC286094
p-tau/Aβ42 rs112959610 13 57488227 G/A (0.465) 2.67 × 10–8   RN7SKP6 PRR20A
p-tau/Aβ42 rs8027714 15 24964597 G/A (0.201) < 5 × 10–9   C15orf2 SNRPN
  1. Chrom Chromosome, MAF minor allele frequency, Maj Major Allele, Min Minor Allele, rQTL relationship quantitative trait loci, SNP single nucleotide polymorphism
  2. aNominally significant for case/control status
  3. bNominally significant for rate of decline
  4. cNominally significant for Aβ42