Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease

Table 2 AUC of CSF biomarkers

	SNAP-25	Aβ42	t-tau	p-tau	SNAP-25/Aβ42	t-tau/Aβ42	p-tau/Aβ42
pMCI	0.72 (0.61–0.82) (p < 0.001)	0.80 (0.70–0.89) (p < 0.001)	0.74 (0.65–0.84) (p < 0.001)	0.78 (0.69–0.88) (p < 0.001)	0.81 (0.72–0.90) (p < 0.001)	0.81 (0.72–0.90) (p < 0.001)	0.81 (0.72–0.90) (p < 0.001)
AD	0.79 (0.67–0.91) (p = 0.002)	0.85 (0.77–0.94) (p < 0.001)	0.87 (0.75–0.98) (p < 0.001)	0.88 (0.80–0.96) (p < 0.001)	0.91 (0.84–0.98) (p < 0.001)	0.91 (0.82–1.00) (p < 0.001)	0.91 (0.84–0.98) (p < 0.001)

Aβ amyloid-β, AD Alzheimer’s disease, AUC area under the receiver operator characteristics curve, CSF cerebrospinal fluid, pMCI progressive mild cognitive impairment, p-tau phosphorylated tau, SNAP-25 synaptosomal-associated protein 25, t-tau total tau

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