Groups compared | Mean (SEM) difference in CSF sTREM2 (ng/ml) | 95% CI for CSF sTREM2 (ng/ml) | P value |
---|---|---|---|
Dementia vs. control | 0.638 (0.806) | −0.966, 2.244 | 0.431 |
Clinical subgroups | |||
 bvFTD vs. control | −0.349 (1.035) | −2.413, 1.713 | 0.736 |
 nfvPPA vs. control | 0.544 (1.009) | −1.468, 2.556 | 0.592 |
 svPPA vs. control | 1.145 (1.129) | −1.107, 3.397 | 0.314 |
 lvPPA vs. control | 1.040 (1.037) | −1.025, 3.106 | 0.319 |
 PPA-NOS vs. control | 1.840 (1.837) | −1.820, 5.502 | 0.320 |
 nfvPPA vs. bvFTD | 0.305 (1.153) | −2.004, 2.615 | 0.792 |
 svPPA vs. bvFTD | 1.344 (1.190) | −1.041, 3.729 | 0.264 |
 lvPPA vs. bvFTD | 0.723 (1.224) | −1.730, 3.176 | 0.557 |
 PPA-NOS vs. bvFTD | 1.228 (1.927) | −2.631, 5.088 | 0.526 |
 svPPA vs. nfvPPA | 1.038 (1.247) | −1.460, 3.537 | 0.409 |
 lvPPA vs. nfvPPA | 0.417 (1.101) | −1.789, 2.624 | 0.706 |
 PPA-NOS vs. nfvPPA | 0.922 (1.939) | −2.961, 4.806 | 0.636 |
 lvPPA vs. svPPA | −0.621 (1.287) | −3.199, 1.957 | 0.631 |
 PPA-NOS vs. svPPA | −0.116 (2.016) | −4.154, 3.923 | 0.954 |
 PPA-NOS vs. lvPPA | 0.505 (1.967) | −3.343, 4.445 | 0.798 |
Genetic subgroups | |||
 GRN vs. control | 2.748 (1.161) | 0.331, 5.163 | 0.028a |
 MAPT vs. control | −2.230 (1.144) | −4.609, 0.149 | 0.065 |
 C9orf72 vs. control | −1.897 (1.266) | −4.529, 0.735 | 0.149 |
 GRN vs. MAPT | 4.978 (1.483) | 1.893, 8.063 | 0.003a |
 GRN vs. C9orf72 | 4.644 (1.536) | 1.448, 7.840 | 0.006a |
 C9orf72 vs. MAPT | 0.334 (1.408) | −2.595, 3.262 | 0.815 |
Pathological subgroups | |||
 AD biomarker-positive dementia vs. controls | 1.921 (0.996) | −0.062, 3.905 | 0.057 |
 AD biomarker-negative dementia vs. controls | 0.183 (0.817) | −1.446, 1.812 | 0.823 |
 AD biomarker-positive dementia vs. AD biomarker-negative dementia | F(2,58) = 3.77, P = 0.029a,b |