| Control | AD biomarker-negative dementia (CSF T-tau/Aβ42 < 1.0) | AD biomarker-positive dementia (CSF T-tau/Aβ42 > 1.0) |
---|---|---|---|
No. of subjects | 17 | 49 | 15 |
Male sex, n (% group) | 6 (54.5) | 36 (73.4) | 9 (60.0) |
Age at CSF, years, mean (SD) | 63.7 (6.4) | 64.1 (6.7) | 65.9 (6.0) |
Age at onset, years, mean (SD) | n/a | 58.6 (6.8) | 62.4 (6.7) |
Disease duration at CSF collection, years, mean (SD); median (IQR) | n/a | 5.6 (4.1); 4.6 (3.1–6.6) | 3.5 (2.1); 2.9 (1.7–5.1) |
CSF sTREM2, ng/ml, mean (SD) | 6.8 (1.6) | 6.9 (3.0) | 9.0 (3.6) |
CSF Aβ42, pg/ml, mean (SD) | 1032.2 (214.3) | 833.9 (265.4) | 510.5 (165.7) |
CSF T-tau, pg/ml, mean (SD) | 332.6 (82.4) | 373.5 (173.0) | 1047.2 (511.3) |
CSF P-tau, pg/ml, mean (SD) | 52.7 (10.6) | 44.8 (15.3) | 97.0 (34.3) |
CSF T-tau/Aβ42 ratio, median (IQR) | 0.3 (0.2–0.5) | 0.4 (0.3–0.7) | 1.6 (1.2–3.2) |