Table 1 Demographic characterization, CSF results, and NfL concentrations in the diagnostic groups

N (male + female)

41 (22 + 19)

25 (10 + 15)

33 (13 + 20)

Age (years)

52.5 ± 13.1

71.3 ± 8.4

70.8 ± 7.6

MMSE

29.3 ± 0.9^a

26.7 ± 2.1^b

21.2 ± 3.4

CSF Aβ1–42 (pg/mL)

1025 ± 308

585 ± 116

536 ± 114

CSF Aβ1–40 (pg/mL)

13,598 ± 4046

19,171 ± 5689

15,309 ± 4172

CSF Aβ42/40

0.076 ± 0.01

0.032 ± 0.01

0.036 ± 0.006

CSF Tau (pg/mL)

198 ± 64.4

631 ± 214

558 ± 178

CSF pTau181 (pg/mL)

37.3 ± 12.1

101.4 ± 29.8

89.9 ± 18.4

Plasma NfL (pg/mL)

22.0 ± 12.4

38.1 ± 15.9

49.1 ± 28.4