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Table 3 APOE ε4 and 18F-AV-1451 to predict cognition

From: Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

Cognitive test Predictors β-coefficients R 2 AIC
APOE ε4+ 18F-AV-1451
MMSE APOE ε4+ −0.581 (P = 0.67) NA 0.056 379.1
18F-AV-1451 NA −3.838 (P = 0.054) 0.112 375.2
APOE ε4+ and 18F-AV-1451 −0.946 (P = 0.48) −4.024 (P = 0.046) 0.12 376.6
ADAS immediate recall APOE ε4+ 0.352 (P = 0.45) NA 0.091 211.7
18F-AV-1451 NA 0.968 (P = 0.14) 0.118 209.9
APOE ε4+ and 18F-AV-1451 0.426 (P = 0.36) 1.03 (P = 0.12) 0.132 211
ADAS delayed recall APOE ε4+ 2.124 (P = 0.01) NA 0.168 260.9
18F-AV-1451 NA 1.724 (P = 0.13) 0.086 266.3
APOE ε4+ and 18F-AV-1451 2.17 (P = 0.01) 1.832 (P = 0.09) 0.214 259.7
TMT-A APOE ε4+ −47.961 (P = 0.03) NA 0.158 634.5
18F-AV-1451 NA 57.62 (P = 0.07) 0.131 636.2
APOE ε4+ and 18F-AV-1451 −44.371 (P = 0.04) 51.109 (P = 0.09) 0.204 633.3
Letter fluency (S) APOE ε4+ 2.537 (P = 0.11) NA 0.167 327.1
18F-AV-1451 NA −0.659 (P = 0.79) 0.123 329.9
APOE ε4+ and 18F-AV-1451 2.54 (P = 0.12) 0.023 (P = 0.99) 0.167 329.1
Animal fluency APOE ε4+ 1.969 (P = 0.27) NA 0.108 340.1
18F-AV-1451 NA −6.637 (P = 0.01) 0.198 334.4
APOE ε4+ and 18F-AV-1451 1.238 (P = 0.47) −6.304 (P = 0.02) 0.207 335.8
AQT-CF APOE ε4+ −9.364 (P = 0.47) NA 0.078 518.4
18F-AV-1451 NA 21.59 (P = 0.23) 0.097 517.3
APOE ε4+ and 18F-AV-1451 −7.717 (P = 0.55) 20.403 (P = 0.26) 0.104 518.9
  1. Linear regression models predicting different cognitive tests. β-coefficients are on the original scales. For each test, models were evaluated with different predictors: APOE ε4, 18F-AV-1451, or both APOE ε4 and 18F-AV-1451 (no interactions). In all cases when APOE ε4 or 18F-AV-1451were significant predictors alone, they remained significant with only minor changes in β-coefficients when adjusted for each other. All models were adjusted for age, sex and education. Comparisons of AIC never favored the combined models, since ΔAIC ranged from −1.2 to 2 for the combined model minus the best (lowest AIC) individual model (a ΔAIC ≤ 2 is generally not considered a meaningful model difference) Significant results (P < 0.05) are indicated in bold ADAS Alzheimer’s disease Assessment Scale, AIC Akaike information criterion, AQT-CF A Quick Test of cognitive speed—color and form, MMSE Mini-Mental State Examination, NA not applicable, TMT-A Trail Making Test-A