Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

Table 2 ¹⁸F-AV-1451 PET and cortical thickness by APOE status

Region	APOE ε4+ (unadjusted)		APOE ε4+ (adjusted for age and sex)		APOE ε4+ (adjusted for CSF Aβ42)
Region	β	P value	β	P value	β	P value
¹⁸F-AV-1451
Medial temporal	−0.039	0.561	−0.011	0.873	−0.047	0.467
Lateral temporal	−0.191	0.123	−0.128	0.269	−0.201	0.106
Lateral parietal	−0.343	0.024	−0.238	0.067	−0.37	0.013
Medial parietal	−0.349	0.015	−0.252	0.044	−0.364	0.011
Frontal	−0.175	0.092	−0.088	0.305	−0.193	0.054
Occipital	−0.221	0.04	−0.187	0.073	−0.228	0.035
Whole cortical	−0.203	0.041	−0.134	0.12	−0.219	0.024
ERC/cortex ratio	0.123	0.049	0.105	0.078	0.128	0.041
Cortical thickness
Medial temporal	−0.022	0.787	0.01	0.899	0.015	0.875
Lateral temporal	0.037	0.496	0.05	0.38	0.046	0.475
Lateral parietal	0.101	0.014	0.097	0.017	0.111	0.024
Medial parietal	0.116	0.002	0.113	0.002	0.125	0.004
Frontal	0.056	0.137	0.057	0.144	0.065	0.137
Occipital	0.042	0.188	0.05	0.128	0.055	0.141
Whole cortical	0.057	0.104	0.063	0.083	0.07	0.093
ERC/cortex ratio	−0.090	0.102	−0.062	0.205	−0.096	0.085

Effects of APOE ε4+ on ¹⁸F-AV-1451 (top part) and cortical thickness (lower part), in different linear regression models Significant results (P < 0.05) are indicated in bold The unadjusted effects correspond to Figs. 1 and 2 CSF cerebrospinal fluid, ERC entorhinal cortex

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