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Table 2 18F-AV-1451 PET and cortical thickness by APOE status

From: Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

Region APOE ε4+
(unadjusted)
APOE ε4+
(adjusted for age and sex)
APOE ε4+
(adjusted for CSF Aβ42)
β P value β P value β P value
18F-AV-1451
 Medial temporal −0.039 0.561 −0.011 0.873 −0.047 0.467
 Lateral temporal −0.191 0.123 −0.128 0.269 −0.201 0.106
 Lateral parietal −0.343 0.024 −0.238 0.067 −0.37 0.013
 Medial parietal −0.349 0.015 −0.252 0.044 −0.364 0.011
 Frontal −0.175 0.092 −0.088 0.305 −0.193 0.054
 Occipital −0.221 0.04 −0.187 0.073 −0.228 0.035
 Whole cortical −0.203 0.041 −0.134 0.12 −0.219 0.024
 ERC/cortex ratio 0.123 0.049 0.105 0.078 0.128 0.041
Cortical thickness
 Medial temporal −0.022 0.787 0.01 0.899 0.015 0.875
 Lateral temporal 0.037 0.496 0.05 0.38 0.046 0.475
 Lateral parietal 0.101 0.014 0.097 0.017 0.111 0.024
 Medial parietal 0.116 0.002 0.113 0.002 0.125 0.004
 Frontal 0.056 0.137 0.057 0.144 0.065 0.137
 Occipital 0.042 0.188 0.05 0.128 0.055 0.141
 Whole cortical 0.057 0.104 0.063 0.083 0.07 0.093
 ERC/cortex ratio −0.090 0.102 −0.062 0.205 −0.096 0.085
  1. Effects of APOE ε4+ on 18F-AV-1451 (top part) and cortical thickness (lower part), in different linear regression models Significant results (P < 0.05) are indicated in bold The unadjusted effects correspond to Figs. 1 and 2 CSF cerebrospinal fluid, ERC entorhinal cortex