Fig. 3
From: In vivo quantification of neurofibrillary tangles with [18F]MK-6240
Chromatography, model compartmentalization, and data fit of [18F]MK-6240. a Chromatogram showing parent compound and metabolite of [18F]MK-6240 in counts per minute (cpm) for representative AD participant. b Reversible two-tissue compartment model with four parameters (2T-CM4k) fit in time–activity curves from posterior cingulate (PCC), temporal, and anterior cingulate (ACC) cortices, as well as cerebellar gray matter (GM) of representative mild cognitive impairment (MCI) individual. c Logan graphical plot became linear approximately 80 min after injection in PCC of representative MCI individual