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Table 1 Demographic, cognitive, and postmortem data by progression status

From: Cognitive composite score association with Alzheimer’s disease plaque and tangle pathology

 

Progressors

Nonprogressors

p value

Effect size

n

87

105

NA

NA

Gender (male/female), n

27/60

54/51

< 0.001

NA

APOE e4 (carrier/noncarrier), n

25/62

18/87

0.06

NA

Age at baseline (years)

78.95 ± 5.93

76.40 ± 6.16

< 0.001

0.42

Age at death (years)

87.84 ± 5.67

84.48 ± 5.61

< 0.001

0.60

Education (years)

18.31 ± 3.22

18.20 ± 3.57

0.82

0.03

MMSE at baseline

28.28 ± 1.78

28.68 ± 1.39

0.08

0.25

MMSE proximate to autopsy

21.92 ± 6.61

28.30 ± 1.29

< 0.001

1.34

Length of follow-up (years)

7.65 ± 3.72

7.23 ± 4.75

0.50

0.10

Baseline composite score

67.24 ± 6.85

69.08 ± 7.37

0.08

0.26

Interval between last

clinic visit and autopsy (months)

0.69 ± 0.55

0.68 ± 0.57

0.95

0.02

Postmortem interval (h)

6.95 ± 5.15

7.11 ± 6.95

0.85

0.03

Brain weight at autopsy (g)

1165.97 ± 131.11

1224.61 ± 142.93

< 0.001

0.43

  1. Values are shown as mean ± standard deviation unless otherwise indicated
  2. Effect size = Cohen’s d
  3. MMSE Mini Mental State Examination, NA not applicable