From: Cognitive composite score association with Alzheimer’s disease plaque and tangle pathology
Progressors | Nonprogressors | p value | Effect size | |
---|---|---|---|---|
n | 87 | 105 | NA | NA |
Gender (male/female), n | 27/60 | 54/51 | < 0.001 | NA |
APOE e4 (carrier/noncarrier), n | 25/62 | 18/87 | 0.06 | NA |
Age at baseline (years) | 78.95 ± 5.93 | 76.40 ± 6.16 | < 0.001 | 0.42 |
Age at death (years) | 87.84 ± 5.67 | 84.48 ± 5.61 | < 0.001 | 0.60 |
Education (years) | 18.31 ± 3.22 | 18.20 ± 3.57 | 0.82 | 0.03 |
MMSE at baseline | 28.28 ± 1.78 | 28.68 ± 1.39 | 0.08 | 0.25 |
MMSE proximate to autopsy | 21.92 ± 6.61 | 28.30 ± 1.29 | < 0.001 | 1.34 |
Length of follow-up (years) | 7.65 ± 3.72 | 7.23 ± 4.75 | 0.50 | 0.10 |
Baseline composite score | 67.24 ± 6.85 | 69.08 ± 7.37 | 0.08 | 0.26 |
Interval between last clinic visit and autopsy (months) | 0.69 ± 0.55 | 0.68 ± 0.57 | 0.95 | 0.02 |
Postmortem interval (h) | 6.95 ± 5.15 | 7.11 ± 6.95 | 0.85 | 0.03 |
Brain weight at autopsy (g) | 1165.97 ± 131.11 | 1224.61 ± 142.93 | < 0.001 | 0.43 |