Controls | nfvPPA | svPPA | lvPPA | tAD | |
---|---|---|---|---|---|
Demographic and clinical | |||||
No. of participants, M/F | 8/9 | 3/6 | 7/3 | 6/1 | 4/6 |
Age, years | 67.7 (5.2) | 69.6 (9.2) | 64.9 (7.6) | 66.3 (6.1) | 70.5 (8.9) |
Handedness (R/L/A) | 16/0/1 | 8/1/0 | 10/0/0 | 7/0/0 | 9/1/0 |
Education, years | 16.2 (2.6) | 14.9 (3.3) | 14.8 (3.3) | 15.1 (2.3) | 14.0 (1.8) |
MMSE (total possible score of 30) | 29.7 (0.5) | 24.4 (5.1) | 25.2 (5.3) | 18.4 (8.0) | 19.1 (5.1) |
Symptom duration, years | NA | 3.6 (1.3) | 5.3 (2.0) | 3.3 (1.3) | 6.1 (3.1) |
PTA best ear (N/mild/moderate) | 4/11/0a | 1/6/1b | 4/6/0 | 3/2/1b | 2/5/0c |
General intellect (IQ) | |||||
WASI Verbal IQ | 127.6 (5.9) | 76.4 (17.7) | 67.5 (22.4) | 60.6 (8.3) | 91.8 (19.3) |
WASI Performance IQ | 121.7 (13.7) | 100.3 (21.8) | 110.1 (21.8) | 79.4 (13.1) | 84.7 (20.3) b |
Episodic memory | |||||
RMT Words (total possible score of 50) | 48.4 (1.9) | 40.3 (7.3) a | 33.4 (5.7) d | 31.0 (7.3) a | 15.7 (3.5) b,e |
RMT Faces (total possible score of 50) | 44.5 (4.4) | 39.1 (4.0)a | 35.0 (6.2) c | 31.7 (5.2) | 18.2 (3.2) b,e |
Working memory | |||||
Digit span forward (maximum) | 7.2 (1.0) | 4.6 (1.4) | 7.2 (1.2) | 4.0 (1.3) b | 6.2 (0.9) |
Spatial span forward (maximum) | 5.5 (0.8)a | 4.8 (1.2) | 5.5 (0.9) | 3.3 (0.8) | NA |
Executive skills | |||||
Digit span reverse (maximum) | 5.1 (1.1) | 3.0 (0.9) b | 5.4 (2.1) | 2.6 (0.9) a | 3.8 (0.8) b |
Spatial span reverse (maximum) | 5.4 (0.9)a | 3.8 (1.5) | 5.2 (1.2) | 3.0 (1.0) | NA |
Letter fluency (total) | 18.4 (5.1) | 6.2 (6.0) | 10.2 (4.5) b | 4.5 (6.5) c | 9.9 (6.0) |
Category fluency (total) | 25.6 (5.4) | 9.7 (4.9) | 17.6 (37.2) b | 5.0 (7.5) | 6.3 (4.9) |
Trails Making Test A (seconds) | 31.8 (8.0) | 71.3 (36.9) | 45.1 (37.2) | 79.2 (37.6) a | 92.8 (40.6) a |
Posterior cortical skills | |||||
GDA Calculation (total possible score of 24) | 13.6 (4.1) | 6.0 (6.4) b | 15.0 (7.3)a | 3.0 (2.2) c | 3.4 (4.4) c |
VOSP Object Decision (total possible score of 20) | 18.9 (1.0) | 17.4 (1.9) | 16.2 (3.1) | 15.3 (2.6) | 15.5 (2.3) |
Neurolinguistic skills | |||||
Auditory input processing | |||||
PALPA-3 (total possible score of 36) | 35.1 (1.1)a | 34.6 (2.3) | 35.3 (1.0) | 31.1 (5.2) | NA |
Word retrieval | |||||
GNT (total possible score of 30) | 27.1 (2.5) | 13.8 (4.8) a | 1.2 (2.2) d | 9.3 (10.3) | 12.7 (9.2) b |
BNT (total possible score of 30) | 29.4 (0.6)a | 22.0 (5.0) | 6.4 (5.2) a | 9.9 (8.5) | NA |
Comprehension | |||||
BPVS (total possible score of 51) | 48.3 (5.6) | 33.3 (14.9) | 9.5 (14.8) | 29.3 (7.3) | 40.1 (5.5) b |
Synonyms concrete (total possible score of 25) | 24.5 (0.6)a | 19.0 (4.2) b | 16.6 (3.3) c | 17.7 (2.8) | NA |
Synonyms abstract (total possible score of 25) | 24.5 (0.8)a | 19.3 (4.5) b | 15.6 (3.6) c | 17.8 (4.0) b | NA |
PALPA-55 (total possible score of 24) | 23.9 (0.4)a | 19.1 (4.5) | 22.3 (2.1)c | 15.7 (4.9) | NA |
Speech repetition | |||||
Polysyllabic words (total possible score of 45) | 44.8 (0.9)a | 35.1 (3.6) b | 48.9 (0.6) | 34.5 (2.6) | NA |
Short sentences (total possible score of 10) | 9.7 (0.6)a | 4.0 (2.9) a | 7.8 (1.7) a | 4.6 (2.2) | NA |
Spelling | |||||
BST (total possible score of 30) | 26.6 (1.6)a | 14.2 (8.0) | 13.0 (7.5) b | 13.0 (7.3) b | NA |