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Table 2 Overview of theoretical arguments in favor or against amyloid positron emission tomography (PET) result disclosure

From: Disclosure of amyloid positron emission tomography results to individuals without dementia: a systematic review

  Cognitively normal Mild cognitive impairment
Category Arguments Research Clinic Research Clinic
Pro
 Ethical Patient autonomy X10,41 X10,41 X39 X5
Evidence of non-maleficence X10,40,41 X10,40,41   
 Social and legal Cost and suffering reduction X38 X38   
Favors Alzheimer’s disease prevention X10 X10   
 Psychological and behavioral Enables early decision making X10,38,41 X10,38,41 X39 X5
Clarifying effect of correct diagnosis X38 X38 X39 X5
Relief related to negative amyloid PET X38,41 X38,41   
Satisfies need for risk information X41 X41   
 PET imaging characteristics Amyloid PET imaging is validated    X39  
Clinical significance of amyloid PET     X5
Contra
 Ethical Non-maleficence X10,38,41 X10,38,41 X39 X5
Lack of effective intervention X10,38 X10,38 X39  
Therapeutic misconception X2 X2   
 Social and legal Unwanted personal implications X38,41 X10,38,41   X5
Social stigmatization X38,41 X38,41   
 Psychological and behavioral Risk of psychological distress X10,38,41 X10,38,41   X5
Risk of false reassurance after negative PET X10,41 X10,41 X39  
Misinterpretation of positive amyloid PET X41 X41   
 PET imaging characteristics Challenges related to inconclusive scans X10,38 X10,38   X5
Limited predictive value at level of individual X10,41 X10,41   
Variation on interpretation of PET results X10 X10