Fig. 2
From: Alzheimer disease pathology and the cerebrospinal fluid proteome
Cerebrospinal fluid (CSF) proteins relevant to Alzheimer pathology. Box plots of CSF proteins according to CSF tau phosphorylated at threonine 181 (P-tau181)/β-amyloid 1–42 (Aβ1–42) ratio (i.e., “high” when P-tau181/Aβ1–42 > 0.0779 [blue dots] and “low” when P-tau181/Aβ1–42 ≤ 0.0779 [red dots]) for positive and negative CSF profiles of AD pathology, respectively, in all subjects (a) and restricted to subjects with cognitive impairment (b). In total, 541 CSF proteins were tested (one by one) in a logistic regression model. P values were corrected for multiple testing using the Benjamini-Hochberg procedure. Box plots were produced for the significant hits presenting false discovery rate ≤ 5%. Relative protein fold change ratios were used (in Log2). Human proteins in the box plots are given by their UniProtKB/Swiss-Prot entry name