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Table 4 Effect of Aβ on MMSE scores over time by diagnostic group

From: The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics

Diagnosis

n

Baseline

p value

Slope

p value

NC

482

− 0.35 ± 0.20

0.170

− 0.60 ± 0.13

< 0.001

MCI

459

− 1.56 ± 0.24

< 0.001

− 0.60 ± 0.14

< 0.001

AD dementia

162

− 0.05 ± 1.05

0.965

− 0.21 ± 0.64

0.742

  1. Numbers are linear mixed-model coefficients ± standard error, relative to the Aβ– group, adjusted for age, gender and years of education
  2. amyloid-beta, AD Alzheimer’s disease, MCI mild cognitive impairment, MMSE Mini Mental State Examination, NC normal cognition