Table 2 Baseline characteristics by clinical diagnosis and Aβ status
From: The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics
Normal cognition | MCI | AD-type dementia | |||||
|---|---|---|---|---|---|---|---|
Aβ– | Aβ+ | Aβ– | Aβ+ | Aβ– | Aβ+ | ||
Total n | n = 365 | n = 127 | n = 220 | n = 307 | n = 27 | n = 175 | |
Age (years) | 1221 | 64.4 (7.6) | 66.9 (7.9)** | 68.3 (8.2) | 70.7 (7.4)*** | 73.0 (8.4) | 69.9 (8.8) |
Female, n | 1221 | 203 (56) | 66 (52) | 108 (49) | 172 (56) | 12 (44) | 96 (55) |
Education (years) | 1221 | 13.5 (3.7) | 12.7 (4.0)* | 10.6 (3.8) | 10.8 (3.7) | 8.5 (4.4) | 10.6 (3.8)** |
APOE ε4 carrier, n | 1221 | 122 (33) | 76 (60)*** | 46 (21) | 200 (65)*** | 7 (26) | 114 (65)*** |
Mean follow-up time (years) | 758 | 2.3 (0.8) | 2.5 (1.1) | 2.2 (1.3) | 2.2 (1.3) | 1.7 (0.9) | 2.2 (1.4) |
MMSE score | 1215 | 28.9 (1.1) | 28.8 (1.2) | 27.0 (2.3) | 25.9 (2.7)*** | 21.5 (5.4) | 21.7 (4.6) |
Memory delayed z-score | 1049 | 0.1 (1.1) | 0.0 (1.2) | −0.9 (1.3) | −1.4 (1.4)*** | −2.2 (1.2) | −2.4 (1.1) |
Language z-score | 1181 | −0.2 (1.0) | −0.1 (1.0) | − 0.7 (1.2) | − 1.0 (2.0) | − 1.9 (1.2) | − 2.3 (2.4) |
Attention z-score | 1128 | 0.3 (1.1) | 0.2 (0.9) | −1.0 (1.8) | −1.0 (1.8) | −2.1 (2.5) | −2.1 (2.0) |
Executive functioning z-score | 976 | 0.3 (1.1) | 0.1 (1.1) | −0.9 (1.9) | −1.4 (2.1)* | −1.2 (2.5) | −3.4 (2.8)* |
Visuoconstruction z-score | 664 | 0.2 (1.4) | 0.2 (0.8) | −0.3 (1.7) | −0.4 (1.8) | −2.1 (2.4) | −1.3 (2.0) |