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Table 2 Association of amyloid-β levels with neurodegenerative markers

From: Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study

Plasma Aβ levels (per SD decrease) Total brain volume, mean difference (95% CI),a p value Total gray matter volume, mean difference (95% CI),a p value Total white matter volume, mean difference (95% CI),a p value Total hippocampal volume, mean difference (95% CI),a p value
1–38 0.03 (− 0.03; 0.08),
p = 0.362
0.02 (− 0.10; 0.15),
p = 0.715
0.01 (− 0.09; 0.12),
p = 0.819
0.04 (− 0.11; 0.19),
p = 0.582
1–40 − 0.04 (− 0.09; 0.02),
p = 0.171
− 0.08 (− 0.21; 0.06),
p = 0.248
0.01 (− 0.11; 0.12),
p = 0.912
− 0.01 (− 0.17; 0.14),
p = 0.869
1–42 0.00 (− 0.03; 0.04),
p = 0.812
− 0.06 (− 0.14; 0.03),
p = 0.174
0.04 (− 0.03; 0.12),
p = 0.251
− 0.13 (− 0.23; − 0.04),
p = 0.007
1–40/Aβ1–42 ratio 0.03 (− 0.02; 0.09)
p = 0.231
0.06 (− 0.07; 0.19),
p = 0.380
−0.00 (− 0.11; 0.11)
p = 0.998
−0.10 (− 0.25; 0.05),
p = 0.194
  1. Abbreviations: amyloid-β, SD standard deviation, CI confidence interval
  2. a Adjusted for age, sex, mean arterial blood pressure, total cholesterol, diabetes, apolipoprotein ε4 carrier status, smoking, intracranial volume and other Aβ levels
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