Fig. 2

Activation state of MR candidates and AD subregulatory network. a Tile plot representing the state of activation of MR candidates (two-tail gene set enrichment analysis) for each case-control expression dataset. b Subregulatory network showing the associations between the significantly activated and repressed MR candidates. Node size represents the number of inferred targets of the master regulator transcription factor candidate; node shape shows their activation state; node color maps their connectivity (subnetwork average degree = 5.75 ± 2.65); edge width shows the Jaccard coefficient of common targets between transcription factor pairs. ns not significant