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Table 1 Demographics, neurolinguistic, and neuropsychological assessment

From: Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia

  Case
  2 4 13 16 17 18 21 3 12 14 19 20 1 5 6 8 10 7 9 11
PPA variant MV MV MV MV MV MV MV NFV NFV NFV NFV NFV SV SV SV SV SV LV LV LV
Age (years) 80 62 76 70 65 49 76 57 68 66 63 70 73 71 63 52 55 77 63 74
Gender M F M M M F F F F F M M F F F F M M F M
Education (years) 17 12 12 12 15 12 12 16 10 15 10 10 14 8 13 13 14 10 12 18
Handedness R L R R R R R R R R R R R R R R R R R R
Symptom duration (months) 33 16 37 39 40 53 24 43 60 74 29 45 19 44 11 131 6 59 95 48
[11C]-PIB SUVR 1.26 2.1 1.35 1.57 1.16 1.37 1.12 1.14 1.2 1.81
CSF Aβ1–42 (pg/ml) 816 477 759 1077 1144 1057 832 887 1558 733 564 664 321
CSF t-tau (pg/ml) 195 442 744 231 265 247 320 270 428 262 407 858
CSF Aβ1–42/t-tau 4.18 1.08 1.02 4.66 4.32 4.28 2.60 3.29 3.64 2.80 1.39 0.37
CSF p181-tau (pg/ml) 42 59.6 87.1 31 39.9 34 43 48 52 36.3 65.7 95
CDR 1 0.5 0.5 0.5 1 0.50 0.5 0.5 0 0.5 0.5 1 0.5 0.5 0.5 0.5 1 0 0.5
MMSE (/30)c 28 28 24 23 5 18 24 18 30 26 26 26 25 29 23 30 26 29 24
CPM (/36)a 26 31 29 29 24 17 29 26 25 26 28 27 34 36 34 32 32 12
BNT (/60)b 52 46 43 41 4 17 48 7 30 47 53 53 11 14 17 9 33 46 57 24
AVF (1 min)b 8 12 7 9 2 5 7 2 13 16 4 7 11 13 6 16 7 23 8
AAT sum single-word comprehension (/60)c 41 49 41 42 37 27 47 56 55 51 53 51 31 32 39 35 58 53 54 50
PALPA auditory word- picture matching (/40)c 40 39 39 39 38 36 37 39 38 40 40 26 27 26 21 39 38 39 38
PALPA verbal assoc.-sem. HI (/15)c 11 15 12 14 11 14 15 10 14 13 10 9 15 12 5 14 15 15 15
PALPA verbal assoc.-sem. LI (/15)c 12 11 14 11 7 5 14 7 12 11 9 3 7 10 6 14 13 14 12
PPT (/52)c 46 47 47 47 47 45 47 48 48 49 48 31 31 38 34 47 49 52 45
BORB easy B (/32)c 28 25 29 28 29 27 31 30 28 30 28 22 19 22 18 25 28 30 26
BORB hard A (/32)c 25 19 22 24 20 20 31 22 26 21 30 17 19 22 17 26 23 26 21
WEZT verb comprehension (/60)b 56 45 55 52 42 49 60 40 42 58 55 43 32 51 48 58 57 57 53
WEZT auditory sentence comprehension (/40)c 36 36 33 31 12 23 29 26 35 33 32 37 33 38 38 39 27 40 37
WEZT active sentence anagram (/10)c 10 10 9 10 5 10 10 9 10 10 10 10 10 10 10 10 10 10 10
WEZT passive sentence anagram (/10)c 10 9 9 5 5 5 10 6 10 10 3 10 9 10 9 10 10 10 10
AAT phoneme repetition (/30)b 24 28 22 20 14 29 27 27 30 27 26 30 29 30 30 30 30 30 29
AAT monosyllabic word repetition (/30)b 28 30 19 30 19 30 29 30 30 24 28 29 28 27 30 30 30 30 29
AAT cognate word repetition (/30)b 29 30 16 29 5 30 28 30 30 29 27 30 30 28 30 30 30 29 29
AAT concatenated word repetition (/30)b 27 29 23 29 1 30 15 29 30 26 25 30 29 28 26 30 15 29 30
AAT sentence repetition (/30)c 27 28 28 28 0 27 17 24 28 25 23 29 29 30 27 30 13 26 24
PALPA single-word repetition (/80)a 77 80 55 77 80 76 79 80 49 76 79 77 77 80 79 79 80 80
PALPA pseudoword repetition (/80)a 21 72 11 57 53 63 72 78 20 59 77 69 67 79 77 66 74 56
DIAS diadochokinesisc 103 50 42 115 75 32 24 51 77 79 18 50 70 147 125 80 77 114 117
DIAS consonant and vowel repetition (/30)c 28 24 12 27 11 28 28 20 30 30 25 27 24 30 30 30 30 30 29
  1. Data in bold are abnormal based on a Crawford and Garthwaite [64] regression method, correcting for educationa or correcting for ageb or depending on the outcome of a Crawford and Howell [52] modified t testc
  2. AAT Aachen Aphasia Test, assoc.-sem associative semantic, 1–42 amyloid-β1–42, AVF Animal Verbal Fluency, BNT Boston Naming Test, BORB Birmingham Object Recognition Battery, CDR Clinical Dementia Rating, [11C]-PIB [11C]-Pittsburgh Compound B, CPM Colored Progressive Matrices, CSF cerebrospinal fluid, DIAS Diagnostisch Instrument voor Apraxie van de Spraak, F female, HI high imageability, L left-handed, LI low imageability, LV logopenic variant, M male, MMSE Mini-Mental State Examination, MV mixed variant, NFV nonfluent variant, PALPA Psycholinguistic Assessment of Language Processing in Aphasia, PPA primary progressive aphasia, PPT Pyramids and Palm trees Test, p181-tau phospho181-tau, R right-handed, SUVR standardized uptake value ratio in a composite cortical volume of interest, SV semantic variant, t-tau total-tau, WEZT Werkwoorden En Zinnen test
  3. – no data collected.