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Table 1 Demographics, neurolinguistic, and neuropsychological assessment

From: Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia

 

Case

 

2

4

13

16

17

18

21

3

12

14

19

20

1

5

6

8

10

7

9

11

PPA variant

MV

MV

MV

MV

MV

MV

MV

NFV

NFV

NFV

NFV

NFV

SV

SV

SV

SV

SV

LV

LV

LV

Age (years)

80

62

76

70

65

49

76

57

68

66

63

70

73

71

63

52

55

77

63

74

Gender

M

F

M

M

M

F

F

F

F

F

M

M

F

F

F

F

M

M

F

M

Education (years)

17

12

12

12

15

12

12

16

10

15

10

10

14

8

13

13

14

10

12

18

Handedness

R

L

R

R

R

R

R

R

R

R

R

R

R

R

R

R

R

R

R

R

Symptom duration (months)

33

16

37

39

40

53

24

43

60

74

29

45

19

44

11

131

6

59

95

48

[11C]-PIB SUVR

–

1.26

2.1

1.35

1.57

–

–

–

–

1.16

1.37

–

–

–

1.12

1.14

1.2

–

1.81

–

CSF Aβ1–42 (pg/ml)

816

–

477

–

759

1077

1144

1057

832

–

–

887

1558

733

–

–

–

564

664

321

CSF t-tau (pg/ml)

195

–

442

–

744

231

265

247

320

–

–

270

428

262

–

–

–

407

–

858

CSF Aβ1–42/t-tau

4.18

–

1.08

–

1.02

4.66

4.32

4.28

2.60

–

–

3.29

3.64

2.80

–

–

–

1.39

–

0.37

CSF p181-tau (pg/ml)

42

–

59.6

–

87.1

31

39.9

34

43

–

–

48

52

36.3

–

–

–

65.7

–

95

CDR

1

0.5

0.5

0.5

1

–

0.50

0.5

0.5

0

0.5

0.5

1

0.5

0.5

0.5

0.5

1

0

0.5

MMSE (/30)c

28

28

24

23

5

–

18

24

18

30

26

26

26

25

29

23

30

26

29

24

CPM (/36)a

26

31

29

29

24

–

17

–

29

26

25

26

28

27

34

36

34

32

32

12

BNT (/60)b

52

46

43

41

4

17

48

7

30

47

53

53

11

14

17

9

33

46

57

24

AVF (1 min)b

8

12

7

9

2

–

5

7

2

13

16

4

7

11

13

6

16

7

23

8

AAT sum single-word comprehension (/60)c

41

49

41

42

37

27

47

56

55

51

53

51

31

32

39

35

58

53

54

50

PALPA auditory word- picture matching (/40)c

40

39

39

39

38

–

36

37

39

38

40

40

26

27

26

21

39

38

39

38

PALPA verbal assoc.-sem. HI (/15)c

11

15

12

14

11

–

14

15

10

14

13

10

9

15

12

5

14

15

15

15

PALPA verbal assoc.-sem. LI (/15)c

12

11

14

11

7

–

5

14

7

12

11

9

3

7

10

6

14

13

14

12

PPT (/52)c

46

47

47

47

47

–

45

47

48

48

49

48

31

31

38

34

47

49

52

45

BORB easy B (/32)c

28

25

29

28

29

–

27

31

30

28

30

28

22

19

22

18

25

28

30

26

BORB hard A (/32)c

25

19

22

24

20

–

20

31

22

26

21

30

17

19

22

17

26

23

26

21

WEZT verb comprehension (/60)b

56

45

55

52

42

–

49

60

40

42

58

55

43

32

51

48

58

57

57

53

WEZT auditory sentence comprehension (/40)c

36

36

33

31

12

–

23

29

26

35

33

32

37

33

38

38

39

27

40

37

WEZT active sentence anagram (/10)c

10

10

9

10

5

–

10

10

9

10

10

10

10

10

10

10

10

10

10

10

WEZT passive sentence anagram (/10)c

10

9

9

5

5

–

5

10

6

10

10

3

10

9

10

9

10

10

10

10

AAT phoneme repetition (/30)b

24

28

22

20

–

14

29

27

27

30

27

26

30

29

30

30

30

30

30

29

AAT monosyllabic word repetition (/30)b

28

30

19

30

–

19

30

29

30

30

24

28

29

28

27

30

30

30

30

29

AAT cognate word repetition (/30)b

29

30

16

29

–

5

30

28

30

30

29

27

30

30

28

30

30

30

29

29

AAT concatenated word repetition (/30)b

27

29

23

29

–

1

30

15

29

30

26

25

30

29

28

26

30

15

29

30

AAT sentence repetition (/30)c

27

28

28

28

–

0

27

17

24

28

25

23

29

29

30

27

30

13

26

24

PALPA single-word repetition (/80)a

77

80

55

77

–

–

80

76

79

80

49

76

79

77

77

80

79

79

80

80

PALPA pseudoword repetition (/80)a

21

72

11

57

–

–

53

63

72

78

20

59

77

69

67

79

77

66

74

56

DIAS diadochokinesisc

103

50

42

115

75

–

32

24

51

77

79

18

50

70

147

125

80

77

114

117

DIAS consonant and vowel repetition (/30)c

28

24

12

27

11

–

28

28

20

30

30

25

27

24

30

30

30

30

30

29

  1. Data in bold are abnormal based on a Crawford and Garthwaite [64] regression method, correcting for educationa or correcting for ageb or depending on the outcome of a Crawford and Howell [52] modified t testc
  2. AAT Aachen Aphasia Test, assoc.-sem associative semantic, Aβ1–42 amyloid-β1–42, AVF Animal Verbal Fluency, BNT Boston Naming Test, BORB Birmingham Object Recognition Battery, CDR Clinical Dementia Rating, [11C]-PIB [11C]-Pittsburgh Compound B, CPM Colored Progressive Matrices, CSF cerebrospinal fluid, DIAS Diagnostisch Instrument voor Apraxie van de Spraak, F female, HI high imageability, L left-handed, LI low imageability, LV logopenic variant, M male, MMSE Mini-Mental State Examination, MV mixed variant, NFV nonfluent variant, PALPA Psycholinguistic Assessment of Language Processing in Aphasia, PPA primary progressive aphasia, PPT Pyramids and Palm trees Test, p181-tau phospho181-tau, R right-handed, SUVR standardized uptake value ratio in a composite cortical volume of interest, SV semantic variant, t-tau total-tau, WEZT Werkwoorden En Zinnen test
  3. – no data collected.