From: Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia
 | Case | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | 2 | 4 | 13 | 16 | 17 | 18 | 21 | 3 | 12 | 14 | 19 | 20 | 1 | 5 | 6 | 8 | 10 | 7 | 9 | 11 |
PPA variant | MV | MV | MV | MV | MV | MV | MV | NFV | NFV | NFV | NFV | NFV | SV | SV | SV | SV | SV | LV | LV | LV |
Age (years) | 80 | 62 | 76 | 70 | 65 | 49 | 76 | 57 | 68 | 66 | 63 | 70 | 73 | 71 | 63 | 52 | 55 | 77 | 63 | 74 |
Gender | M | F | M | M | M | F | F | F | F | F | M | M | F | F | F | F | M | M | F | M |
Education (years) | 17 | 12 | 12 | 12 | 15 | 12 | 12 | 16 | 10 | 15 | 10 | 10 | 14 | 8 | 13 | 13 | 14 | 10 | 12 | 18 |
Handedness | R | L | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R |
Symptom duration (months) | 33 | 16 | 37 | 39 | 40 | 53 | 24 | 43 | 60 | 74 | 29 | 45 | 19 | 44 | 11 | 131 | 6 | 59 | 95 | 48 |
[11C]-PIB SUVR | – | 1.26 | 2.1 | 1.35 | 1.57 | – | – | – | – | 1.16 | 1.37 | – | – | – | 1.12 | 1.14 | 1.2 | – | 1.81 | – |
CSF Aβ1–42 (pg/ml) | 816 | – | 477 | – | 759 | 1077 | 1144 | 1057 | 832 | – | – | 887 | 1558 | 733 | – | – | – | 564 | 664 | 321 |
CSF t-tau (pg/ml) | 195 | – | 442 | – | 744 | 231 | 265 | 247 | 320 | – | – | 270 | 428 | 262 | – | – | – | 407 | – | 858 |
CSF Aβ1–42/t-tau | 4.18 | – | 1.08 | – | 1.02 | 4.66 | 4.32 | 4.28 | 2.60 | – | – | 3.29 | 3.64 | 2.80 | – | – | – | 1.39 | – | 0.37 |
CSF p181-tau (pg/ml) | 42 | – | 59.6 | – | 87.1 | 31 | 39.9 | 34 | 43 | – | – | 48 | 52 | 36.3 | – | – | – | 65.7 | – | 95 |
CDR | 1 | 0.5 | 0.5 | 0.5 | 1 | – | 0.50 | 0.5 | 0.5 | 0 | 0.5 | 0.5 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 0 | 0.5 |
MMSE (/30)c | 28 | 28 | 24 | 23 | 5 | – | 18 | 24 | 18 | 30 | 26 | 26 | 26 | 25 | 29 | 23 | 30 | 26 | 29 | 24 |
CPM (/36)a | 26 | 31 | 29 | 29 | 24 | – | 17 | – | 29 | 26 | 25 | 26 | 28 | 27 | 34 | 36 | 34 | 32 | 32 | 12 |
BNT (/60)b | 52 | 46 | 43 | 41 | 4 | 17 | 48 | 7 | 30 | 47 | 53 | 53 | 11 | 14 | 17 | 9 | 33 | 46 | 57 | 24 |
AVF (1 min)b | 8 | 12 | 7 | 9 | 2 | – | 5 | 7 | 2 | 13 | 16 | 4 | 7 | 11 | 13 | 6 | 16 | 7 | 23 | 8 |
AAT sum single-word comprehension (/60)c | 41 | 49 | 41 | 42 | 37 | 27 | 47 | 56 | 55 | 51 | 53 | 51 | 31 | 32 | 39 | 35 | 58 | 53 | 54 | 50 |
PALPA auditory word- picture matching (/40)c | 40 | 39 | 39 | 39 | 38 | – | 36 | 37 | 39 | 38 | 40 | 40 | 26 | 27 | 26 | 21 | 39 | 38 | 39 | 38 |
PALPA verbal assoc.-sem. HI (/15)c | 11 | 15 | 12 | 14 | 11 | – | 14 | 15 | 10 | 14 | 13 | 10 | 9 | 15 | 12 | 5 | 14 | 15 | 15 | 15 |
PALPA verbal assoc.-sem. LI (/15)c | 12 | 11 | 14 | 11 | 7 | – | 5 | 14 | 7 | 12 | 11 | 9 | 3 | 7 | 10 | 6 | 14 | 13 | 14 | 12 |
PPT (/52)c | 46 | 47 | 47 | 47 | 47 | – | 45 | 47 | 48 | 48 | 49 | 48 | 31 | 31 | 38 | 34 | 47 | 49 | 52 | 45 |
BORB easy B (/32)c | 28 | 25 | 29 | 28 | 29 | – | 27 | 31 | 30 | 28 | 30 | 28 | 22 | 19 | 22 | 18 | 25 | 28 | 30 | 26 |
BORB hard A (/32)c | 25 | 19 | 22 | 24 | 20 | – | 20 | 31 | 22 | 26 | 21 | 30 | 17 | 19 | 22 | 17 | 26 | 23 | 26 | 21 |
WEZT verb comprehension (/60)b | 56 | 45 | 55 | 52 | 42 | – | 49 | 60 | 40 | 42 | 58 | 55 | 43 | 32 | 51 | 48 | 58 | 57 | 57 | 53 |
WEZT auditory sentence comprehension (/40)c | 36 | 36 | 33 | 31 | 12 | – | 23 | 29 | 26 | 35 | 33 | 32 | 37 | 33 | 38 | 38 | 39 | 27 | 40 | 37 |
WEZT active sentence anagram (/10)c | 10 | 10 | 9 | 10 | 5 | – | 10 | 10 | 9 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
WEZT passive sentence anagram (/10)c | 10 | 9 | 9 | 5 | 5 | – | 5 | 10 | 6 | 10 | 10 | 3 | 10 | 9 | 10 | 9 | 10 | 10 | 10 | 10 |
AAT phoneme repetition (/30)b | 24 | 28 | 22 | 20 | – | 14 | 29 | 27 | 27 | 30 | 27 | 26 | 30 | 29 | 30 | 30 | 30 | 30 | 30 | 29 |
AAT monosyllabic word repetition (/30)b | 28 | 30 | 19 | 30 | – | 19 | 30 | 29 | 30 | 30 | 24 | 28 | 29 | 28 | 27 | 30 | 30 | 30 | 30 | 29 |
AAT cognate word repetition (/30)b | 29 | 30 | 16 | 29 | – | 5 | 30 | 28 | 30 | 30 | 29 | 27 | 30 | 30 | 28 | 30 | 30 | 30 | 29 | 29 |
AAT concatenated word repetition (/30)b | 27 | 29 | 23 | 29 | – | 1 | 30 | 15 | 29 | 30 | 26 | 25 | 30 | 29 | 28 | 26 | 30 | 15 | 29 | 30 |
AAT sentence repetition (/30)c | 27 | 28 | 28 | 28 | – | 0 | 27 | 17 | 24 | 28 | 25 | 23 | 29 | 29 | 30 | 27 | 30 | 13 | 26 | 24 |
PALPA single-word repetition (/80)a | 77 | 80 | 55 | 77 | – | – | 80 | 76 | 79 | 80 | 49 | 76 | 79 | 77 | 77 | 80 | 79 | 79 | 80 | 80 |
PALPA pseudoword repetition (/80)a | 21 | 72 | 11 | 57 | – | – | 53 | 63 | 72 | 78 | 20 | 59 | 77 | 69 | 67 | 79 | 77 | 66 | 74 | 56 |
DIAS diadochokinesisc | 103 | 50 | 42 | 115 | 75 | – | 32 | 24 | 51 | 77 | 79 | 18 | 50 | 70 | 147 | 125 | 80 | 77 | 114 | 117 |
DIAS consonant and vowel repetition (/30)c | 28 | 24 | 12 | 27 | 11 | – | 28 | 28 | 20 | 30 | 30 | 25 | 27 | 24 | 30 | 30 | 30 | 30 | 30 | 29 |