Skip to main content

Advertisement

Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Discovery and validation of autosomal dominant Alzheimer’s disease mutations

Fig. 1

Identification of APP, PSEN1, and PSEN2 variants in densely affected Alzheimer’s disease (AD) pedigrees. a–e Pedigrees. Half-shaded triangles represent individuals with a clinical diagnosis of symptomatic AD. Fully shaded triangles represent individuals with autopsy-confirmed symptomatic AD. Diagonal lines represent deceased individuals. Arrows indicate those individuals with DNA, all of whom are mutation/variant carriers. Pedigrees have been masked to maintain anonymity. The pedigree of the PSEN1 M84V family was excluded to prevent potential disclosure of mutation status in asymptomatic mutation carriers

Back to article page