Fig. 1
From: Discovery and validation of autosomal dominant Alzheimer’s disease mutations
Identification of APP, PSEN1, and PSEN2 variants in densely affected Alzheimer’s disease (AD) pedigrees. a–e Pedigrees. Half-shaded triangles represent individuals with a clinical diagnosis of symptomatic AD. Fully shaded triangles represent individuals with autopsy-confirmed symptomatic AD. Diagonal lines represent deceased individuals. Arrows indicate those individuals with DNA, all of whom are mutation/variant carriers. Pedigrees have been masked to maintain anonymity. The pedigree of the PSEN1 M84V family was excluded to prevent potential disclosure of mutation status in asymptomatic mutation carriers