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Table 3 Cognitive performance and decline by Aβ/WMH groups

From: Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

  

Aβ- WMH-

Aβ- WMH+

Aβ + WMH-

Aβ + WMH+

MMSE*

n

140

39

62

27

Baseline

27.79 (27.39, 28.19)

27.52 (26.83, 28.21)

27.20 (26.62, 27.78)

27.40 (26.54, 28.25)

Slope

−0.01 (− 0.15, 0.12)

− 0.29 (− 0.55, − 0.02)

−0.22 (− 0.44, − 0.01)

− 0.31 (− 0.62, 0.00)

Memory delayed recall z-score

n

133

37

58

27

Baseline

−0.48 (− 0.72, − 0.24)B,C,D

−1.04 (− 1.48, − 0.61)A

−1.04 (− 1.41, − 0.68)A

−1.33 (− 1.86, − 0.80)A

Slope

0.05 (− 0.03, 0.13)

0.02 (− 0.12, 0.17)

0.02 (− 0.11, 0.14)

−0.07 (− 0.24, 0.09)

Executive functioning z-score

n

130

37

60

24

Baseline

−0.48 (− 0.76, − 0.21)

−0.41 (− 0.92, 0.09)

−0.78 (− 1.18, − 0.37)

−1.12 (− 1.73, − 0.50)

Slope

0.06 (− 0.02, 0.13)

−0.00 (− 0.15, 0.15)

−0.03 (− 0.16, 0.10)

−0.04 (− 0.23, 0.15)

  1. Results are mean (95% confidence interval). Bold slope estimates = p < 0.05. All analyses were adjusted for study. The analyses on MMSE scores were also corrected for demographics and baseline diagnosis
  2. Abbreviations: amyloid-beta, MMSE mini mental state examination, WMH white matter Hyperintensities
  3. Ap < 0.05 compared to Aβ- WMH-
  4. Bp < 0.05 compared to Aβ- WMH+.
  5. Cp < 0.05 compared to Aβ + WMH-.
  6. Dp < 0.05 compared to Aβ + WMH+.