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Table 1 Comparisons of baseline and follow-up characteristics by Aβ and WMH status

From: Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

 

Aβ- WMH-

Aβ- WMH+

Aβ + WMH-

Aβ + WMH+

n = 140

n = 39

n = 63

n = 29

Baseline characteristics

 Age

61.7 (8.3)B,C,D

71.3 (7.7)A,C

66.7 (7.8)A,B,D

74.1 (5.0)A,C

 Female, n

94 (67)C

23 (59)

32 (51)A

16 (55)

 Education in years

10.9 (3.1)

11.9 (3.3)

11.1 (3.1)

10.3 (2.9)

 Hypertension, n*

43 (34)

9 (25)

15 (25)

9 (32)

 Obesity, n*

15 (14)

3 (11)

4 (8)

4 (21)

 Diabetes, n*

16 (21)

3 (15)

3 (7)

5 (28)

 APOE-ε4 carrier, n*

33 (51)B

5 (24)A,C,D

29 (62)B

10 (56)B

 Diagnosis MCI, n

70 (50)D

21 (54)D

40 (64)

22 (76)A,B

  amnestic MCI (% within MCI group)

40 (57)

15 (71)

27 (68)

17 (77)

  non-amnestic MCI (% within MCI group)

30 (43)

6 (29)

13 (33)

5 (23)

 CSF Aβ 1–42, pg/ml

973.6 (312.0)C,D

885.0 (242.0)C,D

404.3 (102.6)A,B

419.3 (97.2)A,B

 White matter hyperintensities

0.7 (0.5)B,D

2.3 (0.4)A,C

0.8 (0.4)B,D

2.4 (0.5)A,C

Follow-up characteristics

 Follow-up time

2.1 (1.5)

2.2 (1.3)

2.1 (1.2)

2.4 (1.2)

 Time to progression to dementia

1.3 (0.5)B

2.0 (0.7)A

1.7 (0.7)

2.1 (1.2)

 Progression to dementia, n

8 (6)B,C,D

9 (23)A

18 (29)A

11 (38)A

- AD-type dementia, n

2 (1)B,C,D

7 (18)A

18 (29)A

10 (35)A

- Vascular dementia, n

0 (0)

2 (5)

0 (0)

1 (3)

- Frontotemporal dementia, n

4 (3)

0 (0)

0 (0)

0 (0)

- Lewy Body dementia, n

1 (1)

0 (0)

0 (0)

0 (0)

- Dementia with unknown etiology, n

1 (1)

0 (0)

0 (0)

0 (0)

  1. Results are mean (SD) for continuous variables or frequency (%). Hypertension, obesity, diabetes and APOE ε4 genotype were only available in a subgroup of the sample
  2. Abbreviations: amyloid-beta, AD Alzheimer’s disease, APOE Apolipoprotein E, MCI mild cognitive impairment
  3. WMH measured by the Fazekas scale, range 0–3
  4. Ap < 0.05 compared to Aβ- WMH-
  5. Bp < 0.05 compared to Aβ- WMH+
  6. Cp < 0.05 compared to Aβ + WMH-
  7. Dp < 0.05 compared to Aβ + WMH+