Aβ- WMH- | Aβ- WMH+ | Aβ + WMH- | Aβ + WMH+ | |
---|---|---|---|---|
n = 140 | n = 39 | n = 63 | n = 29 | |
Baseline characteristics | ||||
Age | 61.7 (8.3)B,C,D | 71.3 (7.7)A,C | 66.7 (7.8)A,B,D | 74.1 (5.0)A,C |
Female, n | 94 (67)C | 23 (59) | 32 (51)A | 16 (55) |
Education in years | 10.9 (3.1) | 11.9 (3.3) | 11.1 (3.1) | 10.3 (2.9) |
Hypertension, n* | 43 (34) | 9 (25) | 15 (25) | 9 (32) |
Obesity, n* | 15 (14) | 3 (11) | 4 (8) | 4 (21) |
Diabetes, n* | 16 (21) | 3 (15) | 3 (7) | 5 (28) |
APOE-ε4 carrier, n* | 33 (51)B | 5 (24)A,C,D | 29 (62)B | 10 (56)B |
Diagnosis MCI, n | 70 (50)D | 21 (54)D | 40 (64) | 22 (76)A,B |
amnestic MCI (% within MCI group) | 40 (57) | 15 (71) | 27 (68) | 17 (77) |
non-amnestic MCI (% within MCI group) | 30 (43) | 6 (29) | 13 (33) | 5 (23) |
CSF Aβ 1–42, pg/ml | 973.6 (312.0)C,D | 885.0 (242.0)C,D | 404.3 (102.6)A,B | 419.3 (97.2)A,B |
White matter hyperintensities† | 0.7 (0.5)B,D | 2.3 (0.4)A,C | 0.8 (0.4)B,D | 2.4 (0.5)A,C |
Follow-up characteristics | ||||
Follow-up time | 2.1 (1.5) | 2.2 (1.3) | 2.1 (1.2) | 2.4 (1.2) |
Time to progression to dementia | 1.3 (0.5)B | 2.0 (0.7)A | 1.7 (0.7) | 2.1 (1.2) |
Progression to dementia, n | 8 (6)B,C,D | 9 (23)A | 18 (29)A | 11 (38)A |
- AD-type dementia, n | 2 (1)B,C,D | 7 (18)A | 18 (29)A | 10 (35)A |
- Vascular dementia, n | 0 (0) | 2 (5) | 0 (0) | 1 (3) |
- Frontotemporal dementia, n | 4 (3) | 0 (0) | 0 (0) | 0 (0) |
- Lewy Body dementia, n | 1 (1) | 0 (0) | 0 (0) | 0 (0) |
- Dementia with unknown etiology, n | 1 (1) | 0 (0) | 0 (0) | 0 (0) |