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Table 1 Demographic features of the study population

From: Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

   n Total group (N = 151)   Preclinical AD (n = 28) Subthreshold psychiatry (n = 58) Undetermined (n = 65) p
Demographics Age 151 64 ± 8   69 ± 7b 62 ± 8a 64 ± 8a 0.002
Gender, female 151 67 (44)   11 (39) 27 (47) 29 (45) NS
Education (years) 148 12 ± 3   13 ± 3 12 ± 3 12 ± 2 NS
Family history dementia 140 76 (54)   18 (75)b 20 (36)a 38 (62)b 0.002
APOE e4 carrier 144 55 (38)   17 (65)b 17 (30)a 21 (34)a 0.007
    n above cutoff value     
Subjective cognitive decline SCF (1-year change) self-report 150 −1.65 ± 2.98 104 (69) −2.0 ± 2.3 −2.4 ± 3.2 −0.8 ± 2.9b 0.004
CCI (5-year change) self-reportc 148 21.8 ± 14.3 89 (60) 21.4 ± 13.2b 27.8 ± 15.2a 16.7 ± 11.8b 0.000
CCI (5-year change) informantc 127 19.4 ± 17.1 62 (49) 19.8 ± 13.9b 26.4 ± 19.1a 13.8 ± 14.8b 0.000
Mental health questionnaires Quality of Life 149 76 ± 15   79 ± 12 71 ± 16 80 ± 15b 0.012
Depressive symptomsc 150 8.3 ± 6.4 17 (11) 7.0 ± 4.6 12.1 ± 7.3 5.5 ± 4.1 0.000
Anxietyc 150 4.0 ± 2.9 13 (13) 4.1 ± 2.6 5.6 ± 3.1 2.4 ± 1.9 0.000
Distressc 150 6.7 ± 5.9 34 (22) 4.6 ± 4.6 11.1 ± 6.3 3.6 ± 2.9 0.000
Somatizationc 151 6.3 ± 5.3 31 (21) 4.6 ± 3.7 10.3 ± 5.7 3.5 ± 2.8 0.000
Neuroticismc 145 6.6 ± 5.5   5.2 ± 3.8 10.1 ± 6.4 4.0 ± 2.8 0.000
Low masteryc 140 10.5 ± 3.9   10.0 ± 3.0 12.8 ± 4.0 8.5 ± 2.7 0.000
Cognition MMSE 151 28.6 ± 1.2   28.4 ± 1.3 28.5 ± 1.2 28.9 ± 1.2 0.031
 Memory domain RAVLT immediate recall 149 44.3 ± 9.0   43.4 ± 8.7 44.0 ± 9.0 44.6 ± 9.2 NS
RAVLT delayed recall 149 9.0 ± 2.9   8.5 ± 2.9 9.1 ± 3.0 9.2 ± 2.9 NS
RAVLT cued recall 149 28.7 ± 1.6   28.7 ± 1.5 28.5 ± 2.3 28.8 ± 1.4 NS
 Attention TMT Ac 148 34.4 ± 12.8   33.4 ± 12.2b 37.5 ± 14.9a 32.1 ± 10.5b 0.014
 Executive functioning TMT Bc 147 82.1 ± 33.2   79.5 ± 28.9 89.8 ± 41.0 76.2 ± 25.8b 0.058
 Language Animal fluency 147 23.2 ± 5.2   22.8 ± 4.9 23.1 ± 5.1 23.5 ± 5.6 NS
MRI Normalized brain volume (ml) 116 1399 ± 79   1366 ± 75 1407 ± 81 1406 ± 79 NS
Bilateral hippocampal volume (ml) 116 9.9 ± 1.3   10.0 ± 1.4 9.9 ± 1.3 9.8 ± 1.1 NS
White-matter hyperintensities (present) 116 10 (9)   2 (9) 2 (4) 6 (13) NS
Lacunes (> 0) 115 3 (3)   1 (4) 2 (5) 0 (0) NS
Microbleeds present (> 0) 112 19 (17)   7 (30) 4 (10) 8 (17) NS
  1. Unadjusted results presented as mean ± standard deviation or n (%). Differences between groups assessed using age, gender, and education-adjusted analysis of variance or chi-squared tests
  2. AD Alzheimer’s disease, APOE apolipoprotein E genotype, CCI cognitive change index, MMSE Mini-Mental State Examination, MRI magnetic resonance imaging, NS not significant, RAVLT Rey Auditory Verbal Learning Test, SCF subjective cognitive functioning, TMT Trail Making Test
  3. ap < 0.05 difference with preclinical AD
  4. bp < 0.05 difference with subthreshold psychiatry
  5. cHigher scores reflect worse performance or more symptoms