Table 1 Demographic features of the study population

Demographics

Age

151

64 ± 8

69 ± 7^b

62 ± 8^a

64 ± 8^a

0.002

Gender, female

151

67 (44)

11 (39)

27 (47)

29 (45)

NS

Education (years)

148

12 ± 3

13 ± 3

12 ± 3

12 ± 2

NS

Family history dementia

140

76 (54)

18 (75)^b

20 (36)^a

38 (62)^b

0.002

APOE e4 carrier

144

55 (38)

17 (65)^b

17 (30)^a

21 (34)^a

0.007

n above cutoff value

Subjective cognitive decline

SCF (1-year change) self-report

150

−1.65 ± 2.98

104 (69)

−2.0 ± 2.3

−2.4 ± 3.2

−0.8 ± 2.9^b

0.004

CCI (5-year change) self-report^c

148

21.8 ± 14.3

89 (60)

21.4 ± 13.2^b

27.8 ± 15.2^a

16.7 ± 11.8^b

0.000

CCI (5-year change) informant^c

127

19.4 ± 17.1

62 (49)

19.8 ± 13.9^b

26.4 ± 19.1^a

13.8 ± 14.8^b

0.000

Mental health questionnaires

Quality of Life

149

76 ± 15

79 ± 12

71 ± 16

80 ± 15^b

0.012

Depressive symptoms^c

150

8.3 ± 6.4

17 (11)

7.0 ± 4.6

12.1 ± 7.3

5.5 ± 4.1

0.000

Anxiety^c

150

4.0 ± 2.9

13 (13)

4.1 ± 2.6

5.6 ± 3.1

2.4 ± 1.9

0.000

Distress^c

150

6.7 ± 5.9

34 (22)

4.6 ± 4.6

11.1 ± 6.3

3.6 ± 2.9

0.000

Somatization^c

151

6.3 ± 5.3

31 (21)

4.6 ± 3.7

10.3 ± 5.7

3.5 ± 2.8

0.000

Neuroticism^c

145

6.6 ± 5.5

5.2 ± 3.8

10.1 ± 6.4

4.0 ± 2.8

0.000

Low mastery^c

140

10.5 ± 3.9

10.0 ± 3.0

12.8 ± 4.0

8.5 ± 2.7

0.000

Cognition

MMSE

151

28.6 ± 1.2

28.4 ± 1.3

28.5 ± 1.2

28.9 ± 1.2

0.031

 Memory domain

RAVLT immediate recall

149

44.3 ± 9.0

43.4 ± 8.7

44.0 ± 9.0

44.6 ± 9.2

NS

RAVLT delayed recall

149

9.0 ± 2.9

8.5 ± 2.9

9.1 ± 3.0

9.2 ± 2.9

NS

RAVLT cued recall

149

28.7 ± 1.6

28.7 ± 1.5

28.5 ± 2.3

28.8 ± 1.4

NS

 Attention

TMT A^c

148

34.4 ± 12.8

33.4 ± 12.2^b

37.5 ± 14.9^a

32.1 ± 10.5^b

0.014

 Executive functioning

TMT B^c

147

82.1 ± 33.2

79.5 ± 28.9

89.8 ± 41.0

76.2 ± 25.8^b

0.058

 Language

Animal fluency

147

23.2 ± 5.2

22.8 ± 4.9

23.1 ± 5.1

23.5 ± 5.6

NS

MRI

Normalized brain volume (ml)

116

1399 ± 79

1366 ± 75

1407 ± 81

1406 ± 79

NS

Bilateral hippocampal volume (ml)

116

9.9 ± 1.3

10.0 ± 1.4

9.9 ± 1.3

9.8 ± 1.1

NS

White-matter hyperintensities (present)

116

10 (9)

2 (9)

2 (4)

6 (13)

NS

Lacunes (> 0)

115

3 (3)

1 (4)

2 (5)

0 (0)

NS

Microbleeds present (> 0)

112

19 (17)

7 (30)

4 (10)

8 (17)

NS