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Table 3 Intervention effect on incident all-cause dementia across the models, by LIBRA group

From: Modifiable dementia risk score to study heterogeneity in treatment effect of a dementia prevention trial: a post hoc analysis in the preDIVA trial using the LIBRA index

 

LIBRA group

Intervention, n/N (%)

Control, n/N (%)

Hazard ratio (95% CI)

p value for interaction

Model 1: LIBRA index

Low

33/567 (5.8%)

43/524 (8.2%)

0.71 (0.45–1.12)

Ref.

Intermediate

39/576 (6.8%)

32/505 (6.3%)

1.06 (0.66–1.69)

0.23

High

41/606 (6.8%)

32/496 (6.5%)

1.02 (0.64–1.62)

0.27

Model 2: LIBRA index including education

Low

28/555 (5.0%)

39/498 (7.8%)

0.64 (0.40–1.05)

Ref.

Intermediate

38/525 (7.2%)

31/482 (6.4%)

1.11 (0.69–1.79)

0.12

High

46/660 (7.0%)

35/525 (6.7%)

1.03 (0.66–1.59)

0.17

Model 3: LIBRA index including age, sex and education

Low

32/564 (5.7%)

33/515 (6.4%)

0.88 (0.54–1.43)

Ref.

Intermediate

35/568 (6.2%)

34/510 (6.7%)

0.91 (0.57–1.47)

0.94

High

45/608 (7.4%)

38/480 (7.9%)

0.92 (0.59–1.41)

0.92

Model 4: LIBRA index excluding coronary heart disease

Low

36/559 (6.0%)

45/559 (8.1%)

0.75 (0.48–1.16)

Ref.

Intermediate

35/570 (6.1%)

28/477 (5.9%)

1.05 (0.64–1.72)

0.32

High

42/580 (7.2%)

34/489 (7.0%)

1.01 (0.64–1.59)

0.34

  1. LIBRA LIfestyle for BRAin Health, CI confidence interval, Ref. reference category