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Table 3 Intervention effect on incident all-cause dementia across the models, by LIBRA group

From: Modifiable dementia risk score to study heterogeneity in treatment effect of a dementia prevention trial: a post hoc analysis in the preDIVA trial using the LIBRA index

  LIBRA group Intervention, n/N (%) Control, n/N (%) Hazard ratio (95% CI) p value for interaction
Model 1: LIBRA index Low 33/567 (5.8%) 43/524 (8.2%) 0.71 (0.45–1.12) Ref.
Intermediate 39/576 (6.8%) 32/505 (6.3%) 1.06 (0.66–1.69) 0.23
High 41/606 (6.8%) 32/496 (6.5%) 1.02 (0.64–1.62) 0.27
Model 2: LIBRA index including education Low 28/555 (5.0%) 39/498 (7.8%) 0.64 (0.40–1.05) Ref.
Intermediate 38/525 (7.2%) 31/482 (6.4%) 1.11 (0.69–1.79) 0.12
High 46/660 (7.0%) 35/525 (6.7%) 1.03 (0.66–1.59) 0.17
Model 3: LIBRA index including age, sex and education Low 32/564 (5.7%) 33/515 (6.4%) 0.88 (0.54–1.43) Ref.
Intermediate 35/568 (6.2%) 34/510 (6.7%) 0.91 (0.57–1.47) 0.94
High 45/608 (7.4%) 38/480 (7.9%) 0.92 (0.59–1.41) 0.92
Model 4: LIBRA index excluding coronary heart disease Low 36/559 (6.0%) 45/559 (8.1%) 0.75 (0.48–1.16) Ref.
Intermediate 35/570 (6.1%) 28/477 (5.9%) 1.05 (0.64–1.72) 0.32
High 42/580 (7.2%) 34/489 (7.0%) 1.01 (0.64–1.59) 0.34
  1. LIBRA LIfestyle for BRAin Health, CI confidence interval, Ref. reference category