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Table 2 Baseline characteristics by LIBRA group

From: Modifiable dementia risk score to study heterogeneity in treatment effect of a dementia prevention trial: a post hoc analysis in the preDIVA trial using the LIBRA index

  Low LIBRA index Intermediate LIBRA index High LIBRA index p value
Total number of participants 1091 1081 1102  
Range in LIBRA index −1.0 to 2.6 2.6 to 4.2 4.2 to 11.6
Demographics
 Age (years) 74.2 (2.5) 74.3 (2.5) 74.5 (2.5) < 0.01
 Sex (male) 528 (48.4%) 519 (48.0%) 445 (40.4%) < 0.01
Education     < 0.01
 Low (< 7 years) 209 (19.2%) 239 (22.1%) 330 (29.9%)  
 Medium (7–12 years) 695 (63.7%) 671 (62.1%) 660 (59.9%)
 High (> 12 years) 179 (16.4%) 161 (14.9%) 101 (9.2%)
Race (white) 1057 (96.9%) 1042 (96.4%) 1054 (95.6%) < 0.01
Medical history
 CVD (excluding stroke or TIA) 66 (6.0%) 372 (34.4%) 526 (47.7%) < 0.01
 Stroke or TIA 60 (5.5%) 95 (8.8%) 169 (15.3%) < 0.01
Cardiovascular risk factors
 Systolic BP (mmHg) 151.5 (22.0) 157.5 (20.8) 156.7 (20.6) < 0.01
 Diastolic BP (mmHg) 81.0 (10.9) 82.0 (10.9) 81.3 (11.0) 0.09
 Total cholesterol (mmol/L) 5.4 (0.9) 5.4 (1.1) 4.9 (1.2) < 0.01
 LDL cholesterol (mmol/L) 3.3 (0.8) 3.2 (1.0) 2.8 (1.0) < 0.01
 Body mass index (kg/m2) 25.9 (3.1) 26.7 (3.6) 29.6 (4.6) < 0.01
 Type 2 diabetes 30 (2.7%) 103 (9.5%) 460 (41.7%) < 0.01
 Smoking (currently) 46 (4.2%) 113 (10.5%) 265 (24.0%) < 0.01
 Alcohol use (units/week) 3 (0–7) 4 (0–14) 0 (0–10) < 0.01
 Physically active (WHO) 1065 (97.6%) 990 (91.6%) 784 (71.1%) < 0.01
 Creatinine (μmol/L) 77 (68–88) 80 (68–93) 82 (71–97) < 0.01
Medication use
 Antihypertensive medication 332 (30.4%) 631 (58.4%) 838 (76.0%) < 0.01
 Cholesterol-lowering medication 77 (7.1%) 370 (34.2%) 664 (60.3%) < 0.01
Disability and neuropsychiatric assessment
 Mini-Mental State Examination 29 (28–30) 28,5 (27–29) 28 (27–29) < 0.01
 Visual Association Test 6 (5, 6) 6 (5, 6) 6 (5, 6) 0.05
 Geriatric Depression Scale 1 (0–1) 1 (0–2) 2 (0–4) < 0.01
  1. Data presented as number (percentage), mean (standard deviation) or median (interquartile range)
  2. LIBRA LIfestyle for BRAin Health, CVD indicates cardiovascular disease TIA transient ischemic attack, BP blood pressure, LDL low-density lipoprotein, WHO World Health Organisation