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Table 1 Definition of risk/protective factors in the LIBRA index and corresponding scores [11]

From: Modifiable dementia risk score to study heterogeneity in treatment effect of a dementia prevention trial: a post hoc analysis in the preDIVA trial using the LIBRA index

  Definition Score
Modifiable risk factors
 Depression Score ≥ 5 on the 15-item Geriatric Depression Scale + 2.1
 Hypertension SBP ≥ 140 mmHg, DBP ≥ 90 mmHg and/or use of antihypertensive medication + 1.6
 Obesity BMI ≥ 30 + 1.6
 Smoking Current smoker + 1.5
 Hypercholesterolemia Total cholesterol ≥ 6.2 mmol/L or use of cholesterol-lowering medication + 1.4
 Diabetes Diabetes mellitusa + 1.3
 Renal dysfunction Estimated glomerular filtration rate < 60 ml/min/1.73 m2 b + 1.1
 Physical inactivity Not fulfilling World Health Organisation criteria for physical activity as measured with LASA Physical Activity Questionnairec + 1.1
 Coronary heart disease Cardiovascular disease (defined as myocardial infarction, angina or peripheral arterial disease)a + 1.0
 Low/moderate alcohol use Alcohol use 1–14 units per week for males and 1–7 for females [21] −1.0
Non-modifiable risk factors
 Age Males: 70–74 years + 5.2
Male: 75–78 years + 6.8
Females: 70–74 years + 6.2
Female: 75–78 years + 9.2
 Education High: ≥ 13 years 0
Medium: 7–13 years + 1.4
Low: ≤ 7 years + 2.7
  1. LIBRA LIfestyle for BRAin Health, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index
  2. aData self-reported and cross-checked with electronic health records
  3. bEstimated glomerular filtration rate calculated with the creatinine-based Chronic Kidney Disease–Epidemiology Collaboration equation [27]
  4. cWorld Health Organisation criteria for physical activity defined as ≥ 150 min/week moderate intensity or ≥ 75 min/week vigorous intensity or an equivalent combination