Table 1 Cognitive domains by instrument (# = Prone to ceiling (+) or floor (−) effects in mild stage patients)
From: Cognition comes of age: comments on the new FDA draft guidance for early Alzheimer’s disease
Cognitive skill or domain | ADAS-cog subtest | ADCS-PACC | Catch-Cog |
|---|---|---|---|
Episodic verbal memory test | Immediate Word Recall | FCSRT/MMSE | Immediate Word Recall |
Confrontation naming | Naming Fingers and Objects # (+) | MMSE | – |
Tests comprehension and praxis | Commands # (+) | MMSE | – |
Episodic verbal memory test | Delayed Word Recall # (−) | Logical Memory/MMSE | – |
Design copy | Constructional Praxis # (+) | MMSE | – |
Familiar task execution | Ideational Praxis # (+) | MMSE | – |
Semantic & episodic memory | Orientation | MMSE | Orientation |
Episodic verbal memory test | Word Recognition | – | Word Recognition |
Episodic memory | Remembering Test Instructions # (+) | – | – |
Language production | Spoken Language Ability # (+) | MMSE | – |
Semantic memory | Word-finding Difficulty # (+) | MMSE | – |
Language comprehension | Language Comprehension # (+) | MMSE | – |
Attention | Number Cancellation # (+) | DSST | DSST |
Executive skills | Maze # (+) | DSST | DSST, COWAT, CFT, DS |