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Table 1 Formalin-fixed paraffin-embedded cases used for fluorescent immunohistochemistry

From: Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model

Case

GDS

Sex

Age (years)

ABC

Neuropathological diagnosis

Cognitively normal control 1

≤2

M

63

A1,B1,C0

Atherosclerosis

Cognitively normal control 2

≤2

F

71

A0,B1,C0

Atherosclerosis

Cognitively normal control 3

≤2

M

65

A1,B0,C0

Arteriosclerosis

Cognitively normal control 4

≤2

M

69

A0,B0,C0

Normal

Cognitively normal control 5

≤2

M

60

A0,B0,C0

Atherosclerosis

Cognitively normal control 6

2

F

84

A0,B1,C0

Normal

Cognitively normal control 7

2

M

84

A1,B2,C1

ADRC

MCI 1

3

F

97

A1,B2,C1

ADRC

MCI 2

3

M

95

A0,B1,C0

Small vessel disease

MCI 3

3

F

88

A2,B2,C2

ADRC/small vessel disease

MCI 4

3

F

88

A2,B2,C2

ADRC/peripheral vascular disease

MCI 5

3

M

84

A2,B2,C2

Lacunar infarct

MCI 6

3

M

85

A2,B2,C2

CAA

MCI 7

3

F

90

A0,B2,C0

Infarcts/CAA

MCI 8

3

F

83

A2,B2,C2

ADRC/ischemic damage

AD 1

≥5

F

83

A3,B3,C3

AD

AD 2

≥5

F

80

A3,B3,C3

AD

AD 3

≥5

F

80

A3,B3,C3

AD

AD 4

≥5

F

100

A3,B3,C3

AD

AD 5

≥5

M

81

A3,B3,C3

AD

AD 6

≥5

M

84

A3,B3,C3

AD

AD 7

≥5

M

74

A3,B3,C3

AD

AD 8

≥5

M

79

A3,B3,C3

AD

AD 9

≥5

F

91

A3,B3,C3

AD

AD 10

≥5

M

69

A3,B3,C3

AD

AD 11

≥5

M

75

A3,B3,C3

AD

AD 12

≥5

F

88

A3,B3,C3

AD

AD 13

≥5

M

66

A2,B2,C2

AD/CAA

  1. ABC score and neuropathological diagnosis was determined as previously published [31] and reported by a board-certified neuropathologist
  2. AD Alzheimer’s disease, ADRC Alzheimer’s disease-related changes, CAA cerebral amyloid angiopathy, F female, GDS Global Dementia Scale [30], M male, MCI mild cognitive impairment