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Table 1 Formalin-fixed paraffin-embedded cases used for fluorescent immunohistochemistry

From: Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model

Case GDS Sex Age (years) ABC Neuropathological diagnosis
Cognitively normal control 1 ≤2 M 63 A1,B1,C0 Atherosclerosis
Cognitively normal control 2 ≤2 F 71 A0,B1,C0 Atherosclerosis
Cognitively normal control 3 ≤2 M 65 A1,B0,C0 Arteriosclerosis
Cognitively normal control 4 ≤2 M 69 A0,B0,C0 Normal
Cognitively normal control 5 ≤2 M 60 A0,B0,C0 Atherosclerosis
Cognitively normal control 6 2 F 84 A0,B1,C0 Normal
Cognitively normal control 7 2 M 84 A1,B2,C1 ADRC
MCI 1 3 F 97 A1,B2,C1 ADRC
MCI 2 3 M 95 A0,B1,C0 Small vessel disease
MCI 3 3 F 88 A2,B2,C2 ADRC/small vessel disease
MCI 4 3 F 88 A2,B2,C2 ADRC/peripheral vascular disease
MCI 5 3 M 84 A2,B2,C2 Lacunar infarct
MCI 6 3 M 85 A2,B2,C2 CAA
MCI 7 3 F 90 A0,B2,C0 Infarcts/CAA
MCI 8 3 F 83 A2,B2,C2 ADRC/ischemic damage
AD 1 ≥5 F 83 A3,B3,C3 AD
AD 2 ≥5 F 80 A3,B3,C3 AD
AD 3 ≥5 F 80 A3,B3,C3 AD
AD 4 ≥5 F 100 A3,B3,C3 AD
AD 5 ≥5 M 81 A3,B3,C3 AD
AD 6 ≥5 M 84 A3,B3,C3 AD
AD 7 ≥5 M 74 A3,B3,C3 AD
AD 8 ≥5 M 79 A3,B3,C3 AD
AD 9 ≥5 F 91 A3,B3,C3 AD
AD 10 ≥5 M 69 A3,B3,C3 AD
AD 11 ≥5 M 75 A3,B3,C3 AD
AD 12 ≥5 F 88 A3,B3,C3 AD
AD 13 ≥5 M 66 A2,B2,C2 AD/CAA
  1. ABC score and neuropathological diagnosis was determined as previously published [31] and reported by a board-certified neuropathologist
  2. AD Alzheimer’s disease, ADRC Alzheimer’s disease-related changes, CAA cerebral amyloid angiopathy, F female, GDS Global Dementia Scale [30], M male, MCI mild cognitive impairment