Table 1 Demographic details of cohort 1 and cohort 2

n

28

36

20

70

Gender (male:female)

13:15

15:21

14:6

29:41

Age (years) (mean ± SD)

60 ± 7

62 ± 6

62 ± 3

62 ± 5

MMSE (mean ± SD)

27 ± 3

19 ± 5***

28 ± 2

20 ± 6***

Aβ42 (pg/ml) (median [IQR])

915 [815–1026]

468 [395–552]***

1063 [1009–1214]

578 [518–645]***

tTau (pg/ml) (median [IQR])

216 [161–309]

691 [559–962]***

274 [239–315]

734 [552–1021]***

pTau (pg/ml) (median [IQR])

47 [33–54]

92 [77–116]***

43 [39–50]

90 [69–107]***

Contactin-2 (ng/ml) (median [IQR])

78 [69–110]

59 [42–74]***

65 [54–99]

61 [39–78]*