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Table 1 Demographic details of cohort 1 and cohort 2

From: Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer’s disease

  Cohort 1 Cohort 2
Controls Patients with AD Controls Patients with AD
n 28 36 20 70
Gender (male:female) 13:15 15:21 14:6 29:41
Age (years) (mean ± SD) 60 ± 7 62 ± 6 62 ± 3 62 ± 5
MMSE (mean ± SD) 27 ± 3 19 ± 5*** 28 ± 2 20 ± 6***
Aβ42 (pg/ml) (median [IQR]) 915 [815–1026] 468 [395–552]*** 1063 [1009–1214] 578 [518–645]***
tTau (pg/ml) (median [IQR]) 216 [161–309] 691 [559–962]*** 274 [239–315] 734 [552–1021]***
pTau (pg/ml) (median [IQR]) 47 [33–54] 92 [77–116]*** 43 [39–50] 90 [69–107]***
Contactin-2 (ng/ml) (median [IQR]) 78 [69–110] 59 [42–74]*** 65 [54–99] 61 [39–78]*
  1. amyloid beta, AD Alzheimer’s disease, IQR interquartile range, MMSE Mini-Mental State Examination, SD standard deviation
  2. *p < 0.05, **p < 0.01, ***p < 0.001, versus controls