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Table 2 Longitudinal neuropsychological test results for brothers A and B

From: Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study

 

Year

Brother

RAVL

Block design

Digit symbol

Baseline

1995

A

+ 0.74

+ 1.48

+ 1.41

+  2 years

1997

A

+ 0.45

+ 2.00

+ 1.06

+  6 years

2001

A

+ 0.16

+ 1.09

+ 0.97

+  11 years

2006

A

−1.57

+ 0.70

+ 0.37

+  13 years

2008

A

−2.91

−1.64

−1.35

+  14 years

2009

A

−3.30

−1.90

−2.56

Baseline

1995

B

−0.32

+ 1.48

+ 0.80

+  2 years

1997

B

−0.61

+ 2.00

+ 0.54

+  6 years

2001

B

−0.22

+ 0.57

+ 0.11

+  11 years

2006

B

−0.41

+ 0.83

+ 0.63

+  14 years

2009

B

−0.32

+ 1.48

+ 0.46

+  16 years

2011

B

−0.32

+ 1.35

+ 0.57

+  18 years

2013

B

+ 0.16

+ 0.57

+ 0.11

+  22 years

2017

B

+ 0.16

+ 0.96

+ 0.28

  1. RAVL Rey Auditory Verbal Learning
  2. The brothers underwent repeated neuropsychological testing between 1995 and 2017. Numbers in bold are test scores with z less than − 1.5, representing results below the cognitively normal threshold