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Table 3 Sensitivity analyses exploring the association of 25(OH)D with cerebral Aβ

From: Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia

  Unadjusted model Adjusted model
B coefficient or odds ratio* SE or 95% CI* p B coefficient or odds ratio* SE or 95% CI* p
Sensitivity analysis A: 25(OH)D in classesa
 25(OH)D <  20 ng/ml 0.005 0.033 0.869 0.010 0.034 0.775
 25(OH)D ≥ 20 ng/ml ≤ 30 ng/ml 0.061 0.036 0.089 0.039 0.035 0.273
Sensitivity analysis B: logistic regressionb
 25(OH)D < 20 ng/ml 1.021* 0.477,2.188* 0.957 1.038* 0.421,2.557* 0.936
 25(OH)D ≥ 20 ng/ml ≤ 30 ng/ml 1.059* 0.468,2.395* 0.891 0.769* 0.299,1.978* 0.585
Sensitivity analysis C: de-seasonalized 25(OH)D (continuous)c −0.001 0.001 0.600 −0.001 0.001 0.421
  1. aMultiple linear regression was run to explore the associations between cortical Aβ and 25(OH)D classified according to the cut-off values < 20 ng/ml, ≥ 20 but ≤ 30 ng/ml and > 30 ng/ml adjusting for all confounders
  2. bLogistic regression was performed with Aβ dichotomized with a positivity threshold of mean cortical standard uptake value ratio ≥ 1.17 and 25(OH)D in classes with adjustment for all confounders
  3. cDe-seasonalized 25(OH)D values were used to assess the relationship between cortical Aβ and 25(OH)D both as continuous variables using a multiple linear regression model adjusted for all confounders. The adjusted models contained fewer subjects (n = 176) due to missing data on confounders
  4. beta-amyloid, CI confidence interval, SE standard error, 25(OH)D 25-hydroxyvitamin D