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Table 4 Whole-brain voxel-based analyses of 18F-fluorodeoxyglucose positron emission tomographic images in SPM8

From: Metabolic correlates of reserve and resilience in MCI due to Alzheimer's Disease (AD)

  Cluster level Peak level  
Cluster extent Corrected p value Cortical region Maximum z-score   Talairach coordinates   Cortical region BA
Comparison between CTR and patients with “typical” AD
 15,247 0.0001 L-parietal 8.01 − 8 − 73 55 Precuneus 7
   L-limbic 6.05 − 10 − 43 39 Posterior cingulate gyrus 31
   L-parietal 5.04 − 42 − 74 44 Precuneus 19
   L-parietal 5.98 − 44 − 68 49 Inferior parietal lobule 7
   R-parietal 4.89 50 − 47 28 Inferior parietal lobule 40
   L-parietal 4.83 − 12 − 47 34 Precuneus 31
   R-occipital 4.64 30 − 75 24 Precuneus 31
   R-parietal 4.19 10 − 64 47 Precuneus 7
   L-parietal 4.08 − 61 − 53 34 Supramarginal gyrus 40
   L-temporal 4.08 − 65 − 44 10 Superior temporal gyrus 22
   L-parietal 3.93 − 57 − 38 50 Inferior parietal lobule 40
   L-limbic 3.53 − 18 − 58 16 Posterior cingulate gyrus 30
   L-parietal 3.43 − 57 − 38 50 Inferior parietal lobule 40
Comparison between CTR and late-converter patients
 983 0.006 L-parietal 8.83 − 57 − 38 50 Inferior parietal lobule 40
   R-parietal 6.09 50 − 47 28 Inferior parietal lobule 40
   L-parietal 4.01 − 44 − 68 49 Inferior parietal lobule 7
  1. Abbreviations: AD Patients with mild cognitive impairment who clinically converted to dementia of Alzheimer’s type during follow-up, BA Brodmann area, CTR Healthy volunteer control subjects
  2. p < 0.05 corrected for multiple comparisons with the family-wise error correction at both peak and cluster levels was accepted as statistically significant. In the “cluster level” section at left, the corrected p values and the brain lobes with hypometabolism are reported. In the “peak level” section at right, the z-scores and peak coordinates, as well as the corresponding cortical regions and BAs, are reported