Metabolic correlates of reserve and resilience in MCI due to Alzheimer's Disease (AD)

Table 4 Whole-brain voxel-based analyses of ¹⁸F-fluorodeoxyglucose positron emission tomographic images in SPM8

	Cluster level		Peak level
Cluster extent	Corrected p value	Cortical region	Maximum z-score		Talairach coordinates		Cortical region	BA
Comparison between CTR and patients with “typical” AD
15,247	0.0001	L-parietal	8.01	− 8	− 73	55	Precuneus	7
		L-limbic	6.05	− 10	− 43	39	Posterior cingulate gyrus	31
		L-parietal	5.04	− 42	− 74	44	Precuneus	19
		L-parietal	5.98	− 44	− 68	49	Inferior parietal lobule	7
		R-parietal	4.89	50	− 47	28	Inferior parietal lobule	40
		L-parietal	4.83	− 12	− 47	34	Precuneus	31
		R-occipital	4.64	30	− 75	24	Precuneus	31
		R-parietal	4.19	10	− 64	47	Precuneus	7
		L-parietal	4.08	− 61	− 53	34	Supramarginal gyrus	40
		L-temporal	4.08	− 65	− 44	10	Superior temporal gyrus	22
		L-parietal	3.93	− 57	− 38	50	Inferior parietal lobule	40
		L-limbic	3.53	− 18	− 58	16	Posterior cingulate gyrus	30
		L-parietal	3.43	− 57	− 38	50	Inferior parietal lobule	40
Comparison between CTR and late-converter patients
983	0.006	L-parietal	8.83	− 57	− 38	50	Inferior parietal lobule	40
		R-parietal	6.09	50	− 47	28	Inferior parietal lobule	40
		L-parietal	4.01	− 44	− 68	49	Inferior parietal lobule	7

Abbreviations: AD Patients with mild cognitive impairment who clinically converted to dementia of Alzheimer’s type during follow-up, BA Brodmann area, CTR Healthy volunteer control subjects
p < 0.05 corrected for multiple comparisons with the family-wise error correction at both peak and cluster levels was accepted as statistically significant. In the “cluster level” section at left, the corrected p values and the brain lobes with hypometabolism are reported. In the “peak level” section at right, the z-scores and peak coordinates, as well as the corresponding cortical regions and BAs, are reported

ISSN: 1758-9193