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Table 3 Summary of data analysis of changes in MMSE and five neuropsychometric tests reflecting parieto-occipital function

From: A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer's Disease: DONIPAD study

 

Change from baseline of first treatment period to baseline visit of second treatment period (test of carry-over from baseline values)

First treatment period: change from baseline visit to week 6 visit

First treatment period: change from baseline visit to week 12 visit

 

Donepezil (n = 8), mean (SD)

Placebo (n = 10), mean (SD)

Difference (95% CI)

Donepezil (n = 8), mean (SD)

Placebo (n = 10), mean (SD)

Difference (95% CI)

Donepezil (n = 8), mean (SD)

Placebo (n = 10), mean (SD)

Difference (95% CI)

MMSE

2.5 (1.4)

−0.2 (1.7)

2.7 (1.3, 4.0)

1.0 (3.1)

−1.5 (2.4)

2.5 (0.1, 5.0)

1.5 (2.7)

−0.5 (2.4)

2.0 (−0.1, 4.5)

Simple calculation

−0.9 (0.7)a

0.6 (1.1)b

−1.5 (−2.6, –0.8)c

−0.1 (0.7)a

− 0.1 (0.8)b

–0.0 (−0.7, 0.8)c

0.0 (1.3)a

0.4 (1.1)b

−0.4 (−1.4, 0.8)c

    

Donepezil vs placebo 6-week comparison

Donepezil vs placebo 12-week comparison

    

Donepezil first (n = 8), mean (SD)

Placebo first (n = 10), mean (SD)

Combined (n = 18), mean (95% CI)

Donepezil first (n = 8), mean (SD)

Placebo first (n = 10), mean (SD)

Combined (n = 18), mean (95% CI)

Number location

−1.0 (2.2)

−0.9 (1.3)

−0.1 (−1.7, 1.5)

0.8 (1.8)

0.2 (1.5)

0.5 (− 0.1, 1.5)

0.0 (2.4)a

0.7 (2.4)

0.4 (−0.8, 1.4)a

Letter cancellation

−0 (25)a

2 (21)

−2 (−22, 19)a

−7 (39)

−3 (15)

−5 (−19, 8)

−14 (35)a

−1 (14)

−8 (−23, 4)a

Dot counting

−0.3 (1.5)a

−1.0 (2.4)a

0.7 (−1.4, 2.3)b

1.3 (1.8)

−0.2 (1.3)a

0.5 (−0.2, 1.2)a

1.3 (0.8)a

−0.1 (1.7)

0.6 (−0.1, 1.1)a

Digit span

0.3 (1.5)b

0.0 (1.3)b

0.3 (−0.9, 2.0)d

0.6 (1.9)

0.1 (1.6)

0.4 (−0.4, 1.2)

0.0 (1.0)a

−1 (0.8)

−0.5 (−0.9, −0.1)a

  1. CI confidence interval, MMSE Mini-Mental State Examination, SD standard deviation
  2. aOne missing value
  3. bTwo missing values
  4. cThree missing values
  5. dFour missing values