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Table 3 Distribution of Aβ42/40 ratio and further classification of MCI biomarker-based subgroups

From: Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer’s disease dementia in mild cognitive impairment

 

Aβ42/40 ratio < 0.068

Aβ42/40 ratio ≥ 0.068

LL (n = 59)

10 (17%)—IAP

49 (83%)—LL

IAP (n = 21)

14 (67%)—IAP

7 (33%)—LL

SNAP (n = 55)

36 (66%)—HL

19 (34%)—SNAP

HL (n = 62)

56 (90%)—HL

6 (10%)—SNAP

  1. Data expressed as n (percentage) of patients
  2. Aβ42/40 42-aminoacid isoform of amyloid beta/40-aminoacid isoform of amyloid beta, LL Low-AD likelihood, IAP isolated amyloid pathology, SNAP suspected non-Alzheimer pathology, HL high-AD likelihood, AD Alzheimer’s disease
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Alzheimer's Research & Therapy

ISSN: 1758-9193