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# Table 5 AUC (and 95% CI) and specificity (at a fixed sensitivity of 85%) of the ‘top 5’ biomarkers, comparing AD with other neurodegenerative disorders and controls

Diagnostic groups | Biomarker | AUC (95% CI) | Specificity (%)* |
---|---|---|---|

AD vs HC | AβX-42/X-40 ratio | 0.95 (0.92–0.99) | 93% |

Aβ1–42 (pg/mL) | 0.93 (0.88–0.98) | 90% | |

T-tau/Aβ1–42 ratio | 0.93 (0.89–0.97) | 83% | |

T-tau (pg/mL) | 0.81 (0.73–0.90) | 53% | |

P-tau (pg/L) | 0.80 (0.71–0.88) | 54% | |

All the above | 0.91 (0.84–0.95) | 88% | |

AD vs DLB | P-tau (pg/L) | 0.79 (0.68–0.90) | 50% |

T-tau (pg/mL) | 0.78 (0.67–0.88) | 50% | |

T-tau/Aβ1–42 ratio | 0.77 (0.66–0.88) | 40% | |

AβX-42/X-40 ratio | 0.73 (0.59–0.88) | 47% | |

APPβ (ng/mL) | 0.73 (0.58–0.87) | 44% | |

All the above | 0.75 (0.54–0.88) | 50% | |

AD vs bvFTD | T-tau/Aβ1–42 ratio | 0.89 (0.85–0.94) | 70% |

AβX-42/X-40 ratio | 0.86 (0.77–0.94) | 85% | |

T-tau (pg/mL) | 0.83 (0.76–0.90) | 64% | |

Aβ1–42 (pg/mL) | 0.78 (0.70–0.87) | 60% | |

P-tau (pg/L) | 0.78 (0.70–0.86) | 46% | |

All the above | 0.86 (0.78–0.92) | 81% | |

AD vs PNFA | NFL (ng/L) | 0.84 (0.76–0.93) | 50% |

T-tau/Aβ1–42 ratio | 0.67 (0.54–0.80) | 24% | |

Aβ1–42 (pg/mL) | 0.65 (0.50–0.80) | 35% | |

All the above | 0.60 (0.16–0.76) | 42% | |

AD vs SD | AβX-42/X-40 ratio | 0.92 (0.86–0.97) | 100% |

T-tau/Aβ1–42 ratio | 0.91 (0.86–0.96) | 86% | |

Aβ1–42 (pg/mL) | 0.91 (0.84–0.98) | 86% | |

NFL (ng/L) | 0.87 (0.78–0.96) | 67% | |

P-tau (pg/L) | 0.85 (0.75–0.94) | 29% | |

AD vs non-AD dementia | T-tau/Aβ1–42 ratio | 0.82 (0.77–0.88) | 56% |

AβX-42/X-40 ratio | 0.79 (0.72–0.87) | 68% | |

T-tau (pg/mL) | 0.77 (0.71–0.83) | 51% | |

P-tau (pg/L) | 0.76 (0.70–0.83) | 41% | |

Aβ1–42 (pg/mL) | 0.73 (0.67–0.80) | 48% | |

All the above | 0.81 (0.73–0.85) | 68% | |

AD vs all others (including HC) | T-tau/Aβ1–42 ratio | 0.85 (0.80–0.90) | 63% |

AβX-42/X-40 ratio | 0.84 (0.79–0.90) | 76% | |

T-tau (pg/mL) | 0.78 (0.73–0.84) | 51% | |

Aβ1–42 (pg/mL) | 0.78 (0.73–0.84) | 59% | |

P-tau (pg/L) | 0.77 (0.71–0.83) | 45% | |

All the above | 0.84 (0.79–0.90) | 75% |