Biomarker

Cutpoint

95% CI


Lower

Upper


Aβ1–42 (pg/mL)

< 529.0

479.0

647.0

Ttau (pg/mL)

> 312.0

261.0

391.0

Ttau/Aβ1–42 ratio

> 0.64

0.52

1.01

Ptau (pg/L)

> 48.9

42.4

58.7

AβX42/X40

< 0.060

0.055

0.088

APPβ (ng/mL)

> 136.4

115.3

144.6

NFL (ng/L)

< 1877.0

609.8

3149.6

 *For a set sensitivity of 85%, given that AD is always set as the ‘case’ in any comparison, the optimal cutpoint for any specific biomarker is the same regardless of which other diagnostic group is being used as the comparator; it is the specificity that changes for different comparators
 Aβ amyloid beta, AD Alzheimer’s disease, APP amyloid precursor protein, CI confidence interval, NFL neurofilament light chain, Ptau phosphorylated tau, Ttau total tau