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Table 4 Optimal cut-point (95% CI) for AD* at a sensitivity of 85%

From: Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic

Biomarker Cut-point 95% CI
Lower Upper
Aβ1–42 (pg/mL) < 529.0 479.0 647.0
T-tau (pg/mL) > 312.0 261.0 391.0
T-tau/Aβ1–42 ratio > 0.64 0.52 1.01
P-tau (pg/L) > 48.9 42.4 58.7
AβX-42/X-40 < 0.060 0.055 0.088
APPβ (ng/mL) > 136.4 115.3 144.6
NFL (ng/L) < 1877.0 609.8 3149.6
  1. *For a set sensitivity of 85%, given that AD is always set as the ‘case’ in any comparison, the optimal cut-point for any specific biomarker is the same regardless of which other diagnostic group is being used as the comparator; it is the specificity that changes for different comparators
  2. Aβ amyloid beta, AD Alzheimer’s disease, APP amyloid precursor protein, CI confidence interval, NFL neurofilament light chain, P-tau phosphorylated tau, T-tau total tau
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