Biomarker | Cut-point | 95% CI |
|---|
Lower | Upper |
|---|
Aβ1–42 (pg/mL) | < 529.0 | 479.0 | 647.0 |
T-tau (pg/mL) | > 312.0 | 261.0 | 391.0 |
T-tau/Aβ1–42 ratio | > 0.64 | 0.52 | 1.01 |
P-tau (pg/L) | > 48.9 | 42.4 | 58.7 |
AβX-42/X-40 | < 0.060 | 0.055 | 0.088 |
APPβ (ng/mL) | > 136.4 | 115.3 | 144.6 |
NFL (ng/L) | < 1877.0 | 609.8 | 3149.6 |
- *For a set sensitivity of 85%, given that AD is always set as the ‘case’ in any comparison, the optimal cut-point for any specific biomarker is the same regardless of which other diagnostic group is being used as the comparator; it is the specificity that changes for different comparators
- Aβ amyloid beta, AD Alzheimer’s disease, APP amyloid precursor protein, CI confidence interval, NFL neurofilament light chain, P-tau phosphorylated tau, T-tau total tau
