Table 4 Sensitivity analysis: differences between EXPEDITION and GERAS in change from baseline in propensity score-adjusted outcomes

MMSE total score

−0.53

(−1.46, 0.40)

0.06

(−0.62, 0.74)

0.40

(−0.20, 1.00)

NS

ADAS-Cog14 score

1.81

(−0.30, 3.92)

0.66

(−1.06, 2.39)

−0.36

(−1.85, 1.13)

NS

ADCS-ADL basic score

−0.003

(−0.76, 0.75)

0.41

(−0.16, 0.98)

0.67

(0.20, 1.15)

Full only ^a

ADCS-ADL instrumental score

−0.13

(−2.22, 1.96)

1.51

(−0.11, 3.12)

2.42

(1.02, 3.82)

Full only ^a

EQ-5D UK population-based index score

0.03

(−0.02, 0.08)

0.06

(0.02, 0.10)

0.07

(0.03, 0.10)

Full, EU/NA ^b

EQ-5D VAS score

1.51

(−2.42, 5.44)

4.66

(1.69, 7.63)

4.63

(2.01, 7.25)

Full, EU/NA ^b

NPI-12 total score

−0.82

(−3.28, 1.63)

−2.36

(−4.17, −0.56)

−3.11

(−4.67, −1.55)

Full, EU/NA ^b

NPI-12 Caregiver Distress score

−0.11

(−1.49, 1.27)

−1.22

(−2.21, −0.24)

−1.64

(−2.51, −0.78)

Full, EU/NA ^b

Caregiver time on basic ADL (hours/month)

−9.41

(−23.81, 4.99)

−12.27

(−22.91, −1.63)

−9.69

(−19.66, 0.28)

EU/NA only ^c

Caregiver time on instrumental ADL (hours/month)

−26.02

(−42.86, −9.18)

−20.44

(−34.16, −6.72)

−21.96

(−34.52, −9.40)

All ^d

Supervision time (hours/month)

−63.55

(−94.89, −32.22)

−57.33

(−79.81, −34.86)

−57.46

(−77.09, −37.83)

All ^d

Overall caregiver time (hours/month)

−75.01

(−110.37, −39.64)

−71.67

(−98.28, −45.06)

−76.33

(−100.07, −52.58)

All ^d