The left frontal cortex supports reserve in aging by enhancing functional network efficiency

Table 2 Left frontal cortex to default mode network/dorsal attention network connectivity as a mediator of effect of education on default mode network/dorsal attention network small-worldness shown for each functional magnetic resonance imaging task trial type

	DAN		DMN
	Estimate	p Value	Estimate	p Value
Successful encoding
Average causal mediation effect	0.283	0.02	0.396	0.01
Average direct effect	0.214	0.27	0.076	0.57
Total effect	0.497	0.02	0.472	< 0.001
Proportion mediated	0.569	0.04	0.839	0.02
Successful recognition
Average causal mediation effect	0.297	0.02	0.372	< 0.001
Average direct effect	0.224	0.18	0.190	0.29
Total effect	0.521	0.02	0.562	0.01
Proportion mediated	0.570	0.02	0.662	0.01

DAN Dorsal attention network, DMN Default mode network
Mediation models were controlled for age, sex, apolipoprotein E ε4 carrier status, gray matter volume, and task reaction time. Average effects are interpreted as standardized β values and were assessed using nonparametric bootstrapping with 10,000 iterations

ISSN: 1758-9193