TY - JOUR AU - Franzmeier, Nicolai AU - Hartmann, Julia AU - Taylor, Alexander N. W. AU - Araque-Caballero, Miguel Á. AU - Simon-Vermot, Lee AU - Kambeitz-Ilankovic, Lana AU - Bürger, Katharina AU - Catak, Cihan AU - Janowitz, Daniel AU - Müller, Claudia AU - Ertl-Wagner, Birgit AU - Stahl, Robert AU - Dichgans, Martin AU - Duering, Marco AU - Ewers, Michael PY - 2018 DA - 2018/03/06 TI - The left frontal cortex supports reserve in aging by enhancing functional network efficiency JO - Alzheimer's Research & Therapy SP - 28 VL - 10 IS - 1 AB - Recent evidence derived from functional magnetic resonance imaging (fMRI) studies suggests that functional hubs (i.e., highly connected brain regions) are important for mental health. We found recently that global connectivity of a hub in the left frontal cortex (LFC connectivity) is associated with relatively preserved memory abilities and higher levels of protective factors (education, IQ) in normal aging and Alzheimer’s disease. These results suggest that LFC connectivity supports reserve capacity, alleviating memory decline. An open question, however, is why LFC connectivity is beneficial and supports memory function in the face of neurodegeneration. We hypothesized that higher LFC connectivity is associated with enhanced efficiency in connected major networks involved in episodic memory. We further hypothesized that higher LFC-related network efficiency predicts higher memory abilities. SN - 1758-9193 UR - https://doi.org/10.1186/s13195-018-0358-y DO - 10.1186/s13195-018-0358-y ID - Franzmeier2018 ER -