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Table 2 Lewy body symptoms by final neuropathological diagnosis

From: Improving the identification of dementia with Lewy bodies in the context of an Alzheimer’s-type dementia

  AD DLB Mixed AD+DLB  
N = 19 N = 18 N = 22
Core and suggestive symptoms
 Cognitive fluctuations ever 5 (26%) 9 (50%) 8 (36%) X = 2.23, df = 2, P = 0.33
 Complex visual hallucinations at any time 3 (16%) 17 (94%) 11 (50%) X = 23.0, df = 2, P < 0.001
AD vs mixed, X = 5.31, df = 1, P = 0.02
DLB vs mixed, X = 9.30, df = 1, P < 0.01
 Complex visual hallucinations at baseline 1 (5%) 12 (67%) 3 (14%) X = 20.86, df = 2, P < 0.01
AD vs mixed, X = 0.81, df = 1, P = 0.36
DLB vs mixed, X = 11.88, df = 1, P < 0.01
 Complex visual hallucinations emerging later 2 (11%) 5 (28%) 8 (36%) X = 3.67, df = 2, P = 0.16
AD vs mixed, X = 3.69, df = 1, P = 0.055
DLB vs mixed, X = 0.33, df = 1, P = 0.564
 Parkinsonism at any time 4 (21%) 12 (67%) 10 (45%) X = 7.83, df = 2, P = 0.02
AD vs mixed, X = 2.7, df = 1, P = 0.1
DLB vs mixed, X = 1.80, df = 1, P = 0.15
 Parkinsonism at baseline 1 (5%) 8 (44%) 5 (23%) X = 7.86, df = 2, P = 0.02
AD vs mixed, X = 2.49, df = 1, P = 0.13
DLB vs mixed, X = 1.36, df = 1, P = 0.2
 Parkinsonism emerging later 3 (16%) 4 (22%) 5 (23%) X = 0.36, df = 2, P = 0.84
 RBD at any time 4 (21%) 12 (67%) 7 (32%) X = 7.83, df = 2, P = 0.02
AD vs mixed, X = 0.60, df = 1, P = 0.34
DLB vs mixed, X = 4.82, df = 1, P = 0.03
 RBD at baseline 1 (5%) 6 (33%) 0 (0%) X = 11.69, df = 2, P < 0.01
AD vs mixed, X = 1.19, df = 1, P = 0.46
DLB vs mixed, X = 8.63, df = 1, P < 0.01
 RBD emerging later 3 (16%) 6 (33%) 7 (32%) X = 1.83, df = 2, P = 0.4
 Neuroleptic sensitivity at any time 3 (16%) 2 (11%) 3 (14%) X = 0.17, df = 2, P = 0.92
 Exposed to use of neuroleptic 7 (37%) 9 (50%) 12 (55%) X = 1.35, df = 2, P = 0.51
Supportive symptoms
 Falls at any time 7 (37%) 9 (50%) 11 (50%) X = 0.90, df = 2, P = 0.64
 Other hallucinations at any time 1 (5%) 2 (11%) 5 (23%) X = 2.79, df = 2, P = 0.25
 Delusions at any time 3 (16%) 7 (39%) 6 (27%) X = 2.79, df = 2, P = 0.25
 Depression at any time 10 (53%) 9 (50%) 6 (27%) X = 3.30, df = 2, P = 0.19
 Anxiety at any time 11 (58%) 9 (50%) 11 (50%) X = 0.32, df = 2, P = 0.85
 Behavioural disturbance at any time 11 (58%) 8 (44%) 12 (55%) X = 0.73, df = 2, P = 0.70
  1. AD Alzheimer’s disease, DLB dementia with Lewy bodies, RBD REM sleep behaviour disorder
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Alzheimer's Research & Therapy

ISSN: 1758-9193