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Table 2 Brain glucose metabolism correlated with measurement instrument results but not brain amyloid load in patients with Alzheimer’s disease

From: Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

 

Frontal cortex

Parietal cortex

Temporal cortex

Hippocampus

Posterior cingulate cortex

Anterior cingulate cortex

Correlations

r Value

P value

r Value

P value

r Value

P value

r Value

P value

r Value

P value

r Value

P value

FDG SUVR and MMSE

0.47

0.02a

0.45

0.03a

0.62

0.001a

0.35

0.10

0.36

0.09

0.22

0.31

PiB SUVR and MMSE

−0.28

0.19

−0.08

0.71

−0.34

0.12

−0.07

0.74

−0.004

0.87

−0.17

0.45

FDG SUVR and ADL

−0.65

0.008a

−0.40

0.06

−0.56

0.006a

−0.39

0.07

−0.46

0.03a

−0.08

0.72

PiB SUVR and ADL

0.03

0.43

0.01

0.95

0.22

0.30

0.05

0.82

0.02

0.56

0.05

0.82

FDG SUVR and CDR

−0.46

0.03a

−0.12

0.60

−0.43

0.04a

−0.24

0.28

−0.22

0.32

−0.06

0.79

PiB SUVR and CDR

0.14

0.53

−0.01

0.95

0.17

0.44

−0.12

0.57

−0.21

0.34

0.05

0.83

  1. aP < 0.05, P < 0.01 or P < 0.001
  2. Abbreviations: ADL Activities of daily living, CDR Clinical Dementia Rating, FDG 2-[18F]fluoro-2-deoxy-d-glucose, MMSE Mini Mental State Examination, PiB 11C-Pittsburgh compound B, SUVR Standardized uptake value ratio