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Table 1 Characteristics of study subjects

From: Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

Characteristics Control (n = 14) AD for TDP and FDG-PET (n = 14) AD for TDP and PiB-PET (n = 35) AD for FDG and PiB-PET (n = 23)
Male sex, n (%) 6 (42.9) 6 (42.9) 20 (47.1%) 14 (60.9%)
Age, years 68.1 ± 2.9 69.3 ± 2.7 69.4 ± 10.9 68.6 ± 7.83
Education level, years 13.4 ± 0.6 7.5 ± 1.2a 9.9 ± 1.46 8.3 ± 0.75
MMSE score 29.1 ± 0.2 (26-30) 16.6 ± 1.4 (6-24)a 17.6 ± 7.0 a 15.3 ± 8.14a
APOE ε4, n (%) 3 (23.1%)b 10 (71.4%)a 19 (54.3%)a 10 (43.5%)a
Folate, ng/ml 8.8 ± 0.7 9.72 ± 0.90 22.9 ± 3.12
Vitamin B12, pg/ml 499.6 ± 59.1 489.2 ± 47.2 329.4 ± 77.5
TDP, nmol/L 117.1 ± 4.7 84.9 ± 7.1a 101.3 ± 30.3a
SUVR of FDG or PiB in frontal cortex 1.25 ± 0.030 1.10 ± 0.055a 1.9 ± 0.5 1.04 ± 0.02a1.9 ± 0.5
SUVR of FDG or PiB in temporal cortex 1.17 ± 0.028 0.95 ± 0.051a 1.7 ± 0.5 1.05 ± 0.02a2.00 ± 0.08
SUVR of FDG or PiB in parietal cortex 1.16 ± 0.031 0.97 ± 0.044a 1.7 ± 0.4 0.92 ± 0.02a1.96 ± 0.07
  1. Abbreviations: AD Alzheimer’s disease, APOE Apolipoprotein E, FDG 2-[18F]fluoro-2-deoxy-d-glucose, MMSE Mini Mental State Examination, PET Positron emission tomography, PiB 11C-Pittsburgh compound B, SUVR 2-[18F]fluoro-2-deoxy-d-glucose standardized uptake value ratio, TDP Thiamine diphosphate
  2. Data are presented as mean ± SEM or count (percent)
  3. aP < 0.001 vs. control
  4. bUnable to determine for one subject